Refer to NICE guidance and patient information at www.nhsinform.co.uk.

MACROGOL 3350 WITH POTASSIUM CHLORIDE, SODIUM BICARBONATE AND SODIUM CHLORIDE - (First line)

Important: Therapy notes

MHRA advice: Polyethylene glycol (PEG) laxatives and starch-based thickeners: potential interactive effect when mixed, leading to an increased risk of aspiration (April 2021) (www.gov.uk).

  • In adults, the lower volume Movicol-Half® may be useful if fluid volume is a problem, refer to SPC.  
  • In children, refer to Laxido Paediatric Plain® SPC or Movicol Paediatric Chocolate® SPC.
  • If prescribing the 6·563 gram sachets for children ensure that the brand selected is licensed for and contains appropriate dosing instructions for the age of the child.

Important: Formulation and dosage details

Formulation:

Oral powder 13·125 grams/sachet (Laxido Orange®)

Dosage:

In adults:
Chronic constipation: 1 to 3 sachets daily in divided doses usually for up to 2 weeks; maintenance, 1 to 2 sachets daily.
Faecal impaction: 8 sachets daily dissolved in 1 litre water and drunk within 6 hours, usually for maximum 3 days.
Dissolve each sachet in 125mL water. After reconstitution keep the solution in a fridge and discard if unused after 6 hours.

Important: Formulation and dosage details

Formulation:

Sachet 6·563 grams/sachet (Movicol-Half®, Laxido Paediatric Plain®, Movicol Paediatric Chocolate®)

LACTULOSE

Important: Therapy notes

  • Lactulose is less effective than macrogol in the treatment of constipation; it takes 2 to 3 days to work,  is unsuitable on a ‘when required’ basis and frequently causes bloating.

Important: Formulation and dosage details

Formulation:

Solution 3·1 to 3·7 grams/5mL

Dosage:

Hepatic encephalopathy: 30mL 3 times daily, subsequently adjusted to produce 2 to 3 soft stools daily.

Editorial Information

Document Id: F235