TAM (Treatments and Medicines) NHS Highland
| Drug | Amendment | Date formulary amended | Ratification date |
| December 2024 | |||
|
Dorzolamide with timolol Preservative-free eye drops multidose 5mL (dorzolamide 2%, timolol 0·5%) |
Addition | 02/12/24 | 05/12/24 |
|
Ivermectin 3mg tablets |
Addition | 02/12/24 | 05/12/24 |
|
Quizartinib (Vanflyta) film-coated tablets |
Addition | 09/12/24 | 05/12/24 |
|
Spironolactone oral suspension 25mg/ml |
Addition | 09/12/24 | 05/12/24 |
|
Tenecteplase (Metalyse) injection 25mg (5,000 units) |
Addition | 09/12/24 | 05/12/24 |
|
Varenicline 500 microgram, 1mg tablet |
Addition | 09/12/24 | 05/12/24 |
|
Zanubrutinib (Brukinsa) hard capsules |
Additional SMC information | 09/12/24 | 05/12/24 |
| November 2024 | |||
| Aflibercept (Eylea) (30.1mg/263microlitres) 114.3mg/mL solution for intravitreal injection. Dose = 8mg in 70microlitres | Addition | 07/11/24 | 31/10/24 |
| Mavacamten (Camzyos) capsules | Addition | 08/11/24 | 31/10/24 |
|
Mucus clearance device (Aerobika) |
Addition | 07/11/24 | 31/10/24 |
| Pembrolizumab (Keytruda) 25mg/ml concentrate for solution for infusion (SMC2689) | Additional SMC indication | 05/11/24 | 31/10/24 |
| Relugolix (Orgovyx) 120mg film-coated tablets | Addition | 05/11/24 | 31/10/24 |
| Ritlecitinib (Litfulo) hard capsules 50mg | Addition | 07/11/24 | 31/10/24 |
| Selinexor (Nexpovio) 20mg film-coated tablets | Addition | 05/11/24 | 31/10/24 |
| Trifluridine tipiracil (Lonsurf) film-coated tablets, 15mg/6.14mg, 20mg/8.19mg | Addition | 05/11/24 | 31/10/24 |
| September 2024 | |||
|
Adalimumab solution for injection, pre-filled syringe (Amgevita) 20mg/0·4mL, 40mg/0·8mL, solution for injection, pre-filled syringe (Humira) 40mg/0·4mL, solution for injection, pre-filled pen (Amgevita) 40mg/0·8mL and solution for injection, pre-filled pen (Humira) 40mg/0·4mL |
Addition | 11/09/24 | 31/10/24 |
| Buprenorphine (50mg/mL): 8mg, 16mg, 24mg, 32mg prolonged release solution for injection pre-filled syringes (terminal half-life ranging from 3 to 5 days) | Addition | 05/09/24 | 29/08/24 |
| Buprenorphine (355.56mg/mL): 64mg, 96mg, 128mg prolonged release solution for injection pre-filled syringes (terminal half-life ranging from 19 to 25 days) | Addition | 05/09/24 | 29/08/24 |
| Elranatamab solution for injection 40mg/ml | Addition | 11/09/24 | 29/08/24 |
|
Hydroxyzine 10mg/5mL syrup discontinued - amend to Oral syrup 10mg/5mL unlicensed |
Amendment | 13/09/24 | 31/10/24 |
| Ivacaftor with tezacaftor and elexacaftor tablets (Kaftrio®) 37.5mg/25mg/50mg, 75mg/50mg/100mg and granules in sachet (Kaftrio®) 60mg/40mg/80mg, 75mg/50mg/100mg | Addition | 05/09/24 | 29/08/24 |
| Lumacaftor with ivacaftor tablets (Orkambi®) 100mg/125mg, 200mg/125mg andgranules in sachet (Orkambi®) 75mg/94mg, 100mg/125mg, 150mg/188mg | Addition | 05/09/24 | 29/08/24 |
|
Methylphenidate modified release - remove brands |
Amendment | 18/09/24 | 31/10/24 |
| Nivolumab with relatlimab concentrate for solution for infusion | Addition | 05/09/24 | 29/08/24 |
| Pembrolizumab concentrate for solution for infusion 25mg/mL | Addition | 05/09/24 | 29/08/24 |
|
Secukinumab solution for injection in pre-filled pen 150mg, 300mg and solution for injection in pre-filled syringe 150mg, 300mg |
Addition | 11/09/24 | 31/10/24 |
| Teclistamab solution for injection 10mg/ml | Addition | 11/09/24 | 29/08/24 |
| Tezacaftor with ivacaftor tablets (Symkevi®) 50mg/75mg, 100mg/150mg | Addition | 05/09/24 | 29/08/24 |
| Vitamin B complex, Vitamin B compound strong tablets nicotinamide 20mg, pyridoxine hydrochloride 2mg, riboflavin 2mg, thiamine hydrochloride 5mg | Addition | 05/09/24 | 29/08/24 |
| August 2024 | |||
| ActiForm Cool hydrogel 10cm x 15cm | Addition | 13/08/24 | 29/08/24 |
| Compression hosiery formulary: Argyll & Bute only | Addition | 07/08/24 | to go to 31/10/24 |
| July 2024 | |||
| Acetylycysteine effervescent tablets 600mg | Addition | 04/07/24 | 27/06/24 |
| Bimekizumab 160mg solution for injection in pre-filled syringe and pre-filled pen | Addition | 04/07/24 | 27/06/24 |
| Epcoritamab 48mg solution for injection and 4mg/0.8ml concentrate for solution for injection | Addition | 04/07/24 | 27/06/24 |
| Glofitamab 10mg, 2.5mg concentrate for solution for infusion | Addition | 04/07/24 | 27/06/24 |
| Hydrogen peroxide cream 1% 25g tube | Addition | 05/07/24 | 27/06/24 |
| Linaclotide 290 microgram capsule | Addition | 04/07/24 | 27/06/24 |
| Momelotinib 100mg, 150mg, 200mg film coated tablets | Addition | 04/07/24 | 27/06/24 |
| Naldemedine 200 microgram film-coated tablets | Addition | 04/07/24 | 27/06/24 |
| Tirzepatide KwikPen 2.5mg, 5mg, 7.5mg, 10mg, 12.5mg, 15mg solution for injection in prefilled pen | Addition | 04/07/24 | 27/06/24 |
| May 2024 | |||
| Bimekizumab solution for injection in pre-filled syringe and pre-filled pen | Addition | 03/05/24 | 25/04/24 |
| Daratumumab 20mg/mL concentrate for solution for infusion | Addition | 03/05/24 | 25/04/24 |
| Dostarlimab 500mg concentrate for solution for infusion (SMC2635) | Additional SMC indication | 03/05/24 | 25/04/24 |
| Finerenone 10mg, 20mg tablets | Addition | 03/05/24 | 25/04/24 |
| Ivosidenib 250mg film-coated tablets (SMC2615) | Addition | 03/05/24 | 25/04/24 |
| Loncastuximab tesirine 10mg powder for concentrate for solution of infusion (SMC2609) | Addition | 03/05/24 | 25/04/24 |
| Olaparib 100mg, 150mg tablets (SMC2617) | Additional SMC indication | 03/05/24 | 25/04/24 |
| Roxadustat 20mg, 50mg, 70mg, 100mg, 150mg tablets | Addition | 03/05/24 | 25/04/24 |
| Secukinumab solution for injection in pre-filled pen 150mg, 300mg and solution for injection in pre-filled syringe 150mg, 300mg | Addition | 11/09/24 | to go to 31/10/24 |
| Talazoparib 0.25mg, 1mg capsules (SMC2607) | Addition | 03/05/24 | 25/04/24 |
| Vortioxetine 5mg, 10mg, 20mg tablets | Addition | 03/05/24 | 25/04/24 |
| April 2024 | |||
| Atogepant 10mg, 60mg tablets | Addition | 22/04/24 | 29/02/24 |
| Dexcom One+ | Addition | 30/04/24 | 25/04/24 |
| Freestyle Libre 2 Plus | Addition | 30/04/24 | 25/04/24 |
| Nicotine - Lozenge mini (Niquitin Minis Lozenge®) 2mg | Addition | 19/04/24 | 27/06/24 |
| Rimegepant oral lyophilisate 75mg | Addition | 22/04/24 | 29/02/24 |
| March 2024 | |||
| Buprenorphine with naloxone 16mg/4mg sublingual tablets | Addition | 04/03/24 | 29/02/24 |
| FreeStyle Libre 3 rt-CGM (real time continuous glucose monitoring system) | Addition | 04/03/24 | 29/02/24 |
| Lurasidone 18.5mg, 37mg, 74mg film-coated tablets | Addition | 11/03/24 | 29/02/24 |
| Nivolumab 10mg/ml concentrate for solution for infusion (SMC2619) | Additional SMC indication | 05/03/24 | 29/02/24 |
| Pembrolizumab 25mg/ml concentrate for solution for infusion (SMC2589) | Additional SMC indication | 05/03/24 | 29/02/24 |
| Prucalopride tablets 2mg | Addition | 27/03/24 | 29/02/24 |
| Tafamidis capsules 61mg | Addition | 13/03/24 | 29/02/24 |
| Trastuzumab deruxtecan 100mg powder for concentrate for solution for infusion (SMC2608) | Additional SMC indication | 05/03/24 | 29/02/24 |
| February 2024 | |||
| Acalabrutinib 100mg tablets | Addition | 09/02/24 | 29/02/24 |
| January 2024 | |||
| Iloprost 50microgram/0.5m concentrate for solution for infusion ampoules | Addition | 29/01/24 | 29/02/24 |
Formulary updates
| Drug | Amendment | Date formulary amended | Ratification date |
| December 2023 | |||
| Aviptadil with phentolamine mesilate 25 micrograms/2mg in 0.35ml solution for injection SMC1284/17 | Addition | 22/12/23 | 07/12/23 |
| Durvalumab 50mg/ml solution for infusion SMC2582 | Additional SMC indication | 12/12/23 | 07/12/23 |
| Emollin aerosol spray | Addition | 12/12/23 | 07/12/23 |
| Eptinezumab 100mg concentrate for solution for infusion SMC2547 | Addition | 12/12/23 | 07/12/23 |
| Formoterol fumarate with glycopyrronium and budesonide 5mcg/7.2mcg/160mcg pressurised inhalation, suspension (Trixeo® Aerosphere) SMC2321 | Addition | 22/12/23 | 07/12/23 |
| Ozanimod 0.23mg, 0.46mg and 0.92mg hard capsules SMC2478 | Addition | 12/12/23 | 07/12/23 |
| Risankizumab 600mg/10mL concentrate for solution for infusion vial and 360mg/2.4mL solution for injection cartridge SMC2534 | Addition | 12/12/23 | 07/12/23 |
| Selpercatinib 40mg and 80mg capsules SMC2573 | Additional SMC indication | 12/12/23 | 07/12/23 |
| November 2023 | |||
| Aprostadil urethral stick 500, 1000 microgram | Addition | 22/11/23 | 07/12/23 |
| Atezolizumab 1,875mg/15mL (125mg/mL) solution for injection (subcutaneous) | Addition (new formulation) | 10/11/23 | 07/12/23 |
| Lanreotide ipsen | Name change - previously called Somatuline Autogel | 13/11/23 | 07/12/23 |
| Risankizumab 150mg/mL pre-filled pen and pre-filled syringe SMC2196 | Addition | 21/11/23 | 07/12/23 |
| October 2023 | |||
| Cenobamate tablets SMC2408 | Addition | 31/10/23 | 26/10/23 |
| DRUG | REASON FOR DELETION | SUBGROUP MEETING |
| Acalabrutinib capsules | discontinued - use tablets | February 2024 |
| Acetic acid spray 2% | discontinued | August 2019 |
| Aciclovir eye ointment 3% (Zovirax®) | discontinued | January 2019 |
| ActiForm Cool hydrogel 10cm x 10cm | No longer used in NTC - in its place use 10 x 15cm instead. | August 2024 |
| Adrenaline/epinephrine injection 1 in 1,000: disposable syringe 1mg/mL (Minijet®) | discontinued - use 1 in 1,000 solution for injection pre-filled syringe (1mg/mL) instead. | April 2024 |
| Adrenaline/epinephrine injection 1 in 10,000 1mg/10mL (Minijet®) | discontinued - use 1 in 10,000 dilute solution for injection pre-filled syringe (1mg/10mL) instead. | April 2024 |
| Alphosyl shampoo | discontinued | February 2023 |
| Alprostadil 250 microgram urethral application (MUSE®) | discontinued | April 2020 |
| Betamethasone 0.1% eye ointment | discontinued | April 2020 |
| Biphasic Isophane insulin Injection 25% soluble, 75% isophane 100 units/mL 3mL cartridge (Insuman® Comb 25 for ClikSTAR®, Autopen®) and 3mL pre-filled pen (Insuman Comb 25 SoloStar®) | discontinued | February 2023 |
| Biphasic Isophane insulin Injection 50% soluble, 50% isophane 100 units/mL and 3mL cartridge (Insuman® Comb 50 for ClikSTAR®, Autopen®) | discontinued | February 2023 |
| Buprenorphine with naloxone film, all strengths | discontinued | February 2024 |
| Calcium syrup (calcium 2·5mmol or 102mg/5mL) unlicensed | discontinued | October 2022 |
| Calcium polystyrene sulphonate powder (Calcium Resonium) | UKKA Oct 23: no role for Ca resonium for acute hyperkalaemia | December 2024 |
| Cervarix vaccine suspension for injection 0.5ml pre-filled syringes | discontinued | June 2021 |
| Ciprofloxacin 3mg/mL, dexamethasone 1mg/mL (Cilodex) ear drops | discontinued | April 2021 |
| Clozapine oral suspension 50mg/ml | Formulary review; use 25mg and 100mg orodisperisble tablets | April 2022 |
| Collagenase | discontinued | December 2020 |
| Cyclo-progynova 2mg tablets | discontinued | April 2020 |
| Daclatasvir 30mg and 60mg tablets | discontinued | November 2019 |
| Dasabuvir 250mg tablets | discontinued | February 2021 |
| Deferiprone 500mg tablets | discontinued | November 2019 |
| Dermamist 10% spray | discontinued | October 2022 |
| Desflurane Inhalation vapour 1mL/1mL | No longer used | February 2022 |
| Dexamethasone soluble tablets 2mg, 4mg, 8mg | Formulary review; standard tablets can be dispersed in water | December 2021 |
| Diazepam emulsion for injection 10mg/2mL | Discontinued - no replacement identified (solution for injection not used at Raigmore). | August 2024 |
| Diazepam rectal solution tubes 2.5mg/1.25mL | removed due to unavailability | December 2021 |
| Dicobalt Edetate 300mg/20mL injection | discontinued - replaced with Sodium nitrite solution for injection | May 2020 |
| Dihydrocodeine 10mg/5ml oral solution | discontinued | February 2021 |
| Diprobase cream and ointment | Formulary review; Zeroderma range first line choice | February 2021 |
| Dithranol (Dithrocream) 2% cream | discontinued | April 2021 |
| Dithranol (Dithrocream®) 0.25%, 0.5% and 1% cream | discontinued | April 2022 |
| Doublebase® Gel | replaced with Zerodouble® Emollient Gel | January 2019 |
| Engerix B 20microgram/1mL | discontinued | April 2021 |
| Enzalutamide 40mg capsules | discontinued - replaced with enzalutamide tablets | April 2020 |
| Epaderm ointment | Formulary review, Zeroderma range first line choice | February 2021 |
| Estradiol (Vagifem) | Vagirux preferred brand for environmental reasons | October 2021 |
| Ethinylestadiol and norethisterone (Loestrin) 20 and 30 tablets | discontinued | October 2019 |
| Exenatide injection, pre-filled pen 5 micrograms/dose, 10 micrograms/dose and prolonged-release suspension for injection 2mg/pre-filled pen | discontinued | April 2024 |
| Exenatide modified release powder for reconstitution 2mg/pre-filled pen | discontinued - use prolonged-release suspension for injection 2mg/pre-filled pens | October 2022 |
| Flecainide 200mg modified release tablets | discontinued | April 2020 |
| Fluphenazine decanoate solution for injection (oily) 12.5g/0.5mL, 25mg/1mL 100mg/1mL | discontinued | August 2021 |
| Fluticasone propionate/ formoterol 125 microgram/5 microgram (Flutiform® K-haler®) | discontinued | April 2021 |
| Gynest 0.01% estriol | Formulary review - estriol cream of choice: estriol 0.1% | August 2020 |
| Haloperidol 500 microgram capsules | discontinued | April 2020 |
| Hep A + Typhoid (viatim) | discontinued | April 2024 |
| Human papillomavirus (type 16, 18) vaccine (absorbed) suspension for injection 0.5ml pre-filled syringes | discontinued | June 2021 |
| Hydrocortisone 10% rectal foam | discontinued | April 2020 |
| Hydrocortisone (as acetate) (aqueous suspension) 25mg/1mL injection | discontinued | April 2022 |
| Ibandronic acid infusion 2mg/2mL and 6mg/6mL | no longer used for malignant disease | May 2019 |
| Infliximab powder for concentrate for solution for infusion 100mg (Remicade®) | Formulary review - Remsima should be used | June 2021 |
| Infliximab powder for concentrate for solution for infusion 100mg | Formulary review - Inflectra, Remsima and Zessly brands should be used | April 2022 |
| Insuman Comb 25 100units/ml suspension for injection 5ml vials | discontinued | June 2021 |
| Insulin glargine injection 100 units/mL 3mL cartridge (Abasaglar® for Autopen®) and (Lantus for ClikSTAR, Autopen®24) | discontinued | February 2023 |
| Irriclens 240ml aerosol | Not used in Highland | October 2024 |
| Isophane insulin 100 units/mL 5mL vial (Insuman® Basal) injection | discontinued | April 2022 |
| Isophane insulin 10mL vial (Insulatard®), removed 3mL cartridge (Insuman® Basal for ClikSTAR, Autopen®), (Humulin I® for Autopen®) and 3mL pre-filled pen (Insuman Basal SoloStar®) | discontinued | February 2023 |
| Isoprenalin injection 2mg/2mL unlicensed (hospital use only) | Use licensed version | April 2022 |
| Macrogol 3350 with anhydrous sodium sulfate, potassium chloride, sodium bicarbonate and sodium chloride (Vista-Prep®) | discontinued | August 2024 |
| Macrogol 3350 with anhydrous sodium sulfate, potassium chloride, sodium bicarbonate and sodium chloride (Klean-prep®) | Discontinued. NB - to remain on Formulary until stock is used up. | August 2024 |
| Macrogol 3350 with potassium chloride, sodium bicarbonate and sodium chloride (Klean-Prep) oral powder 69g/sachet | Formulary review - VistaPrep should be used | October 2021 |
| Magnesium hydroxide Mixture BP | alternative products available | December 2020 |
| Mannitol (Viaflex®) | discontinued | August 2019 |
| Mepolizumab power for solution for injection vials | discontinued | October 2024 |
| Mesalazine 400mg and 800mg (Asacol® brand only) | May 2019 | |
| Mesalazine foam enema (Asacol®) | discontinued | October 2021 |
| Methotrexate subcutaneous all strengths (Zlatal® brand only) | Formulary review - Methofill should be used | December 2020 |
| Nepafenac 1mg/ml eye drops | Replaced by nepafenac 3mg/ml eye drops | June 2021 |
| Nicotine - Lozenge mini (Niquitin Minis Lozenge®) 1.5mg | Discontinued - use 2mg | June 2024 |
| Norethisterone acetate and ethinylestradiol (Loestrin®) | discontinued | November 2019 |
| Ofatumumab concentrate for solution for infusion 20mg/mL | discontinued | February 2021 |
| Orlistat capsules | No longer recommended by NHS Highland. See the NHS Highland Adult Healthy Weight pathway. | January 2019 |
| Pembrolizumab 50mg powder for infusion | discontinued | June 2022 |
| Phytomenadione | Konakion brand discontinued | February 2025 |
| Pirfenidone 267mg capsules | discontinued - use tablets | June 2022 |
| Pralsetinib hard capsules 100mg | discontinued | October 2024 |
| Prazosin 1mg tablets | discontinued | April 2022 |
| Prednisolone retention enema 20mg/100mL | discontinued | August 2019 |
| Prednisolone foam enema 20mg/metered application (as metasulfobenzoate sodium) | Formulary review - budesonide rectal foam 2mg/dose should be used | February 2022 |
| Ranitidine 75mg/5ml oral solution sugar free | discontinued | June 2021 |
| Ranitidine 150mg and 300mg effervescent tablets | discontinued | June 2021 |
| Ranitidine 150mg and 300mg tablets | discontinued | February 2022 |
| Risankizumab 75mg/0.83mL | discontinued - alternative is 150mg/mL pre-filled pen and pre-filled syringe | December 2023 |
| Selegeline oral lyophilisate tablet 1.25mg | discontinued | December 2020 |
| Simeprevir capsules 150mg | discontinued | February 2021 |
| Sitagliptin 25mg, 50mg and 100mg tablets | replaced with alogliptin | August 2019 |
| Sodium aurothiomalate 10mg/0∙5ml and 50mg/0∙5ml injection | discontinued | August 2021 |
| Sodium chloride 4∙5% eye drops | discontinued - replaced by sodium chloride 5% preservative free eye drops | August 2021 |
| Somatropin (Norditropin Simplexx®) 5mg/1∙5ml, 10mg/1∙5ml and 15mg/1∙5ml solution for injection | replaced with Norditropin Flexpro | August 2021 |
| Theophylline (Slo-Phyllin®) 60mg, 125mg and 250mg | discontinued | February 2020 |
| Tolterodine 1mg and 2mg tablets and 4mg modified release | replaced with solifenacin | April 2020 |
| Triamcinolone acetonide 10mg/1ml suspension for injection ampoules | discontinued | February 2021 |
| Ulipristal acetate (Esmya) 5mg tablets | discontinued | April 2021 |
| Varenicline tablets 500 microgram, 1mg, starter pack | discontinued | October 2022 |
| Viekirax 12.5mg, 50mg and 75mg tablets | discontinued | February 2021 |
| VitA-POS eye ointment preservative free | discontinued - replaced with Hylo Night | August 2021 |
| Xerotin® oral spray | not available | January 2019 |
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