CLOTRIMAZOLE

Important: Therapy notes

Important: Formulation and dosage details

Formulation:

Solution 1%

Dosage:

Apply into ear 2 to 3 times daily continuing for at least 14 days after infection disappears.

CIPROFLOXACIN

Important: Therapy notes

MHRA advice: Flouroquinolone antibiotics: must now only be prescribed when other commonly recommended antibiotics are inappropriate.  Updated safety advice is available here including a patient information leaflet.  Side effects may be disabling, long-lasting and sometimes irreversible.  Systems affected include musculoskeletal (tendonitis/rupture), neurological (muscle weakness), sensory (peripheral neuropathy) and psychiatric (tiredness, anxiety, depression and suicidal thoughts).  Fluoroquinolones should not be prescribed for self-limiting or mild to moderate infections or non-bacterial (chronic) prostatitis (January 2024).

MHRA alert: Fluoroquinolone antibiotics: new restrictions and precautions for use due to very rare reports of disabling and potentially long-lasting or irreversible side effects (March 2019) (www.gov.uk).

Important: Formulation and dosage details

Formulation:

Single-dose ear drops 2mg/mL

Dosage:

Apply contents of 1 single ampoule into the ear twice daily for 7 days.

As per SMC 1230/18: treatment of acute otitis externa in adults and children older than 1 year
with an intact tympanic membrane, caused by ciprofloxacin susceptible microorganisms. 
SMC restriction: when off-label or unlicensed ciprofloxacin formulations would otherwise be used. 

Editorial Information

Document Id: F151