Important: Therapy notes
- Exclude pregnancy before treatment and ensure effective contraception during and for one month after stopping treatment.
Important: Formulation and dosage details
Formulation:
Capsules 61mg (Restricted: Specialist use only)
Dosage:
- SMC2585: for the treatment of wild-type and hereditary transthyretin amyloidosis in adult patients with cardiomyopathy (ATTR-CM).
- Patients will be initiated on treatment by cardiology.
- Patients will be reviewed 6-monthly in the cardiology clinic throughout treatment.
- Decision to stop can be made in primary care, eg if the patient’s clinical condition has changed and the patient is considered to have end-stage illness or unacceptable drug intolerance. Cardiology should be informed via Clinical Dialogue.