Blood-related products (Formulary)

TAM (Treatments and Medicines) NHS Highland
NHS Highland

For further information see blood products table below. 

Supplementary notes

Product/SPC

Indication 

Who authorises use

Who supplies product

Beriplex® (dried prothrombin complex injection 500 units)

Warfarin antidote (see SPC)

Consultant Haematologist authorisation required.  Can then be prescribed by junior medical staff or appropriate non-medical prescribers.

Blood Transfusion Services (BTS)/Laboratory staff on behalf of Pharmacy (as required as part of group of products that may be supplied to manage condition).

NovoSeven® (eptacog afa (activated) factor VIIa (recombinant) injection 1mg, 2mg)

Factor VII deficiency, treatment of severe postpartum haemorrhage.

Consultant Haematologist authorisation required. 

Inpatients or emergencies: Hospital Pharmacy.

Veyvondi® (vonicog alfa rVWF 1,300 units)

Von Willebrand disease, prophylasis and treatment of bleeding 18 years and over.

Consultant Haematologist authorisation required.  

Inpatients or emergencies: Hospital Pharmacy
Homecare patients: Homecare company.

Voncento® (FVIII/VWF) 1000 units (1000 units FVIII/2400 units VWF)

Von Willebrand disease, prophylaxis and treatment of bleeding.

Haemophilia A, prophylaxis and treatment of bleeding.

Consultant Haematologist authorisation required.  

 Inpatients or emergencies: Hospital Pharmacy
Homecare patients: Homecare company.
Refacto AF® (moroctocog alfa recombinant factor VIII injection 250 units, 1000 units, 2000 units, 3000 units)

Haemophilia A, treatment and prophylaxis of bleeding.

Consultant Haematologist authorisation required.   

Inpatients or emergencies: Hospital Pharmacy
Homecare patients: Homecare company.

Esperoct® (turoctocog alfa pegol) factor VIII, 1000 units, 2000 units

Haemophilia A, treatment and prophylaxis of bleeding in patients 12 years and over.

Consultant Haematologist authorisation required.  

Inpatients or emergencies: Hospital Pharmacy
Homecare patients: Homecare company. 

Hemlibra® (emicizumab) 60mg/0.4mL, 105mg/0.7mL

Haemophilia A, prophylaxis of bleeding.

Consultant Haematologist authorisation required.   

 Inpatients: Hospital Pharmacy
Homecare patients: Homecare company. 

BeneFIX® (nonacog alfa, factor IX injection 1000 units, 2000 units

Haemophilia B, treatment and prophylaxis of bleeding.

Consultant Haematologist authorisation required.   

Inpatients or emergencies: Hospital Pharmacy
Homecare patients: Homecare company. 

Rixubis® (nonacog gamma) Factor IX 1000 units

Haemophilia B, treatment and prophylaxis of bleeding.

Consultant Haematologist authorisation required. 

Inpatients or emergencies: Hospital Pharmacy
Homecare patients: Homecare company. 

Idelvion® (albutrepenonacog alfa) factor IX 1000 units

Haemophilia B, treatment and prophylaxis of bleeding. 

Consultant Haematologist authorisation required.   

Inpatients or emergencies: Hospital Pharmacy
Homecare patients: Homecare company.  

Riastap® (human fibrinogen) 1 gram

Dysfibrinogenaemia, treatment of bleeding

Consultant Haematologist authorisation required.   

Inpatients or emergencies: Hospital Pharmacy.

DRIED PROTHROMBIN COMPLEX

Therapy notes

Dried prothrombin complex (Beriplex®) is used in addition to vitamin K in patients who are bleeding and on warfarin or in whom surgical intervention is planned imminently and the bleeding risk is thought to be unacceptable (note for certain procedures reversal may not be required; discuss with Haematologist). It provides temporary but immediate reversal of anticoagulation. It can be obtained from the Blood Transfusion Service on the authorisation of a Haematologist.

Note:

  • Idarucizumab (Praxbind®) is used for the reversal of dabigatran, prior to emergency surgery or in patients with life-threatening or uncontrolled bleeding.
  • Andexanet alfa (Ondexxya®) is used for the rapid reversal of apixaban or rivaroxaban, in adults ≥18 years who have taken either drug in the past 48 hours and present with life-threatening or uncontrolled bleeding.
  • There is no licensed antidote available yet for edoxaban. Discuss with haematologist regarding reversal options for edoxaban.

Formulation and dosage details

Formulation:

Injection 500 units (Beriplex®)

Dosage:

EPTACOG ALFA (ACTIVATED), RECOMBINANT FACTOR VIIA

Therapy notes

Formulation and dosage details

Formulation:

Injection 1mg, 2mg (NovoSeven®)

Dosage:

  • Factor VII deficiency: treatment of bleeding
  • Postpartum haemorrhage: treatment of severe bleeding

VONICOG ALFA, RECOMBINANT VWF

Therapy notes

Formulation and dosage details

Formulation:

Injection 1,300 units (Veyvondi®)

Dosage:

  • Von Willebrand disease: prevention and treatment of bleeding

FACTOR VIII/VON WILLEBRAND FACTOR

Therapy notes

Formulation and dosage details

Formulation:

Injection 1,000 units FVIII/2,400 units VWF (Voncento®)

Dosage:

  • Von Willebrand disease: prevention and treatment of bleeding
  • Haemophilia A: prevention and treatment of bleeding

MOROCTOCOG ALFA, RECOMBINANT FACTOR VIII

Therapy notes

Formulation and dosage details

Formulation:

Injection 250 units, 1,000 units, 2000 units, 3000 units (ReFacto AF®)

Dosage:

  • Haemophilia A: prevention and treatment of bleeding

TUROCTOCOG ALFA PEGOL, RECOMBINANT FACTOR VIII

Therapy notes

Formulation and dosage details

Formulation:

Injection 1000 units, 3000 units (Esperoct®)

Dosage:

  • Haemophilia A: prevention and treatment of bleeding

NONACOG ALFA, RECOMBINANT FACTOR IX

Therapy notes

Formulation and dosage details

Formulation:

Injection 1,000 units, 2,000 units (BeneFIX®)

Dosage:

  • Haemophilia B: prevention and treatment of bleeding

NONACOG GAMMA, RECOMBINANT FACTOR IX

Therapy notes

Formulation and dosage details

Formulation:

Injection 1,000 units, (Rixubis®)

Dosage:

  • Haemophilia B: prevention and treatment of bleeding

ALBUTREPENONACOG ALFA, RECOMBINANT FACTOR IX WITH ALBUMIN

Formulation and dosage details

Formulation:

Injection 1,000 units (Idelvion®)

Dosage:

  • Haemophilia B: prevention and treatment of bleeding

FIBRINOGEN/THROMBIN

Formulation and dosage details

Formulation:

Medicated sponge (Tachosil®)

Dosage:

  • During surgery: to stop bleeding and to seal the surfaces of internal organs

Editorial Information

Last reviewed: 29/06/2023

Next review date: 29/06/2026

Approved By: TAM Subgroup

Reviewer name(s): Laura Adamu-Ikeme.

Document Id: F035