Important:
Therapy notes
For reversal of warfarin anticoagulation seek advice from Consultant Haematologist.
Prothrombin complex is used in addition to vitamin K in patients who are bleeding and on warfarin or who are anticoagulated and requiring urgent surgery. It provides temporary but immediate reversal of anticoagulation and can be obtained from the Blood Transfusion Service on the authorisation of a Haematologist.
Important:
Formulation and dosage details
Formulation:
Injection 10mg/mL (specialist use only)
Important:
Formulation and dosage details
Formulation:
Injection, in a mixed micelles vehicle 2mg/0·2mL
Dosage:
Patients with abnormal coagulation due to vitamin K deficiency or patients on warfarin who are bleeding or who have a high INR. It may take up to 6 to 12 hours to act. The dose and route of administration depends on the indication; if in doubt, discuss with the Consultant Haematologist.
Can be administered by intramuscular, intravenous or oral route.
Important:
Formulation and dosage details
Formulation:
Ampoules for injection (IV) 10mg/1mL
Dosage:
Patients with abnormal coagulation due to vitamin K deficiency or patients on warfarin who are bleeding or who have a high INR. It may take up to 6 to 12 hours to act. The dose and route of administration depends on the indication; if in doubt, discuss with the Consultant Haematologist.