Propofol (Neonatal Formulary) | Right Decisions

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Neonatal Formulary
Propofol (Neonatal Formulary)

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PROPOFOL injection 200mg in 20mL (1%)

Indication

Premedication for intubation
Less-invasive surfactant administration (LISA)

DRUG	DOSE	DOSES/DAY	ROUTE
Propofol 200mg in 20mL (1%)	1mg/kg	Once daily	IV

Notes

More mature babies often need higher dose
pH is 6 to 8.5

Preparation

Can be administered undiluted or can be diluted.
Slow IV injection over 60 seconds, followed by slow IV flush of 2mL 0.9% sodium chloride.
If needed, dose can be repeated once (maximum 2 doses per 24 hour period).
Propofol must NOT be administered via a microbiological filter (filters with a pore size less than 5μm).

Solution compatibility	Glucose 5%, sodium chloride 0.9%
IV line compatibility	aminophylline, calcium gluconate, fentanyl, furosemide, heparin, insulin, ketamine, milrinone, noradrenaline, potassium chloride
IV line incompatibility	amphotericin, atracurium, calcium chloride, ceftazidime, gentamicin, phenytoin, vancomycin

This list is not exhaustive, please contact Pharmacy for further information on compatibility with any medicines not included.

Cautions, contra-indications & side effects

See Summary of Product Characteristics and BNF for Children
There is a risk of hypotension when giving propofol

Licensed status

Licensed

Administer reconstituted solutions immediately.

All vials, ampoules and infusion bags are for single use only unless otherwise stated.
Dose may vary depending on indication, age, renal function, hepatic function, and concomitant medications.
This monograph should be used in conjunction with the package insert, BNF for Children, and Summary of Product Characteristics.
For further advice contact your clinical pharmacist or pharmacy department.