Elevated Plasma Viscosity (Guidelines)
Audience
- Highland HSCP
Causes
- Infection
- Inflammation e.g. autoimmune disease, polymyalgia rheumatica
- Raised fibrinogen concentration
- Malignancy
- Increased immunoglobulins, polyclonal or clonal
- Myeloma or lymphoma
- Trauma
- Sarcoid
History and examination
Evaluate for any infective cause and look for any signs or symptoms of autoimmune disease. Ask about night sweats, bone pains and weight loss. Examine for lymphadenopathy and splenomegaly. Look at older blood results.
Suggested investigations
- Full blood count and blood film
- Autoimmune screen if appropriate or suggestive
- Tests for infective aetiology
- Calcium
- Immunoglobulins and serum protein electrophoresis
- If no obvious cause consider chest radiograph and abdominal imaging
Management
This depends on the underlying cause and degree of suspicion. If there are no results or features to suggest haematological malignancy we do not review patients with an elevated PV.