Severe Allergic Reactions

Anaphylaxis is a life-threatening allergic reaction due to the rapid onset of airway/breathing and/or circulatory problems. The early signs & symptoms of anaphylaxis may be mild such as flushing, itchy rash or swelling of the face and abdominal pain/vomiting but they are not always present. It can be triggered by: Foods (e.g. nuts), Medicines (e.g. antibiotics), Venom (e.g. bee and wasp venom), Latex (e.g. balloons, rubber gloves)

Nuts                   Medicines                  Venom               Latex

Signs & symptoms of Anaphylaxis

Airway and Breathing Problems:

Lungs
  • Persistent Cough
  • Hoarse voice/high pitched sound (stridor)
  • Difficulty swallowing, swollen tongue
  • Difficulty or noisy breathing
  • Wheeze

Low Blood Pressure affecting the Consciousness Level:

Heart beat

  • Sudden tiredness/ sleepy
  • Collapse/ loss of consciousness
  • Persistent dizziness
  • Pale or floppy

If any one (or more) of these signs above are present follow the Emergency Response to Anaphylaxis. The symptoms of anaphylaxis may be different depending on the individual. The allergic reaction may also start as mild and progress rapidly to severe.

Treatment of anaphylaxis = Adrenaline

Important information - be alert
Anaphylaxis should ALWAYS be treated with an adrenaline autoinjector (e.g. EpiPen) and an ambulance must be called for further treatment and observation in hospital.
Symptoms of anaphylaxis can return hours after the initial reaction. This is known as a biphasic reaction.

Adrenaline is the first line treatment and should be administered without delay if signs of a severe allergic reaction (anaphylaxis) are suspected. The adrenaline treats both the symptoms of the reaction and also stops the reaction by preventing the further release of chemicals causing anaphylaxis.

Lungs

Heart beat

Relieves breathing problems by relaxing restricted airways

Increases blood pressure by improving heart function (blood output and circulation)

Important information - be aware
Anyone in the community can administer adrenaline via an AAI (e.g. EpiPen) if the intention is to save a life.
If in doubt of the allergic reaction’s severity, it should be treated as severe and adrenaline administered via an AAI. Go to WebsiteHuman Medicines Regulations 2017

How is adrenaline administerered?

A pre-loaded injection device containing adrenaline called adrenaline auto-injector (AAI) is used.  The devices are available in two strengths; junior and adult. They can be administered through clothes and should be injected into the upper outer thigh muscle, in line with the instructions issued for each brand of injector.

Brands of auto-injectors prescribed in the UK include EpiPen, Jext and Emerade. Each brand has been built differently requiring a slightly different administration technique, but all will have the same effect in the body – deliver adrenaline.

Positioning a younger child to administer an AAI:

Positioning a small child for administration of and adrenaline autoinjector          Positioning a small child for administration of an adrenaline autoinjector

Positioning an older child presenting with anaphylaxis symptoms:

a. Lying down with legs elevated where possible

Positioning a child with low blood pressure for administration of adrenaline autoinjector          Positioning a child with low blood pressure for administration of adrenaline autoinjector

b. If patient is struggling to breathe, sit up, but this should be for as short a time as possible

Positioning an older child for administration of an adrenaline autoinjector          Positioning an older child for administration of an adrenaline autoinjector

Follow the links below to watch how to use each brand:

AAI Shortage

One type of AAI is recommended in all settings to avoid confusion over the administration technique. However, over the last 2-3 years, there has been a shortage of AAI’s. In light of this, at times different brands were offered to patients for school use and to carry in their emergency bags.

Updates on the AAI shortage can be found at on the Go to WebsiteMHRA or Go to WebsiteBSACI web pages.

Who is at risk of anaphylaxis?

Food allergy affects up to 8% of school age children. Approximately 25% of school age allergy patients will have their first allergic reaction in school. The majority of the allergic reactions present with mild to moderate symptoms and they do not progress to anaphylaxis (even in children with history of anaphylaxis).
Fatal allergic reactions are rare but they are very unpredictable. In the UK, 17% of fatal allergic reactions in school-aged children happen while at school.

The factors that can increase the severity of a reaction include:

Clock with exclamation mark Couple, one standing and one walking Blue asthma inhaler
Delay in Adrenaline administration Standing or Walking during Anaphylaxis Asthma

Not all patients with allergies are issued an AAI; allergic patients undergo a risk assessment by the healthcare professional to identify the risk of anaphylaxis that they run. A number of factors are assessed; such as additional health conditions (i.e. asthma), previous episodes of severe allergic reactions/anaphylaxis, reactions to very small amounts (traces) of allergens or remoteness to hospitals/ambulance access.

Important information - take note
It is paramount that all staff know the school’s emergency response protocol to anaphylaxis. They should receive training in the management of allergy and anaphylaxis to stay prepared for such emergencies.