People with personality disorder are frequently prescribed medications for physical health conditions. There is a complex interplay between physical health, mental health and the medications used in the treatment of these conditions. Medications like some analgesics and other sedating drugs can sometimes negatively impact on both mental health and general functioning and it is recommended that regular holisitic review of the risk-benefit balance for the patient occurs for all prescribed medications. This can be usefully carried out in liaison between primary care, mental health services and other specialist services, for example pain management services.