Medication for co-occurring mental illness

If there is co-occurring mental illness, this should be treated with medication as appropriate. People with co-occurring personality disorder are often excluded from randomised controlled trials for mental state disorders. This has an impact on the generalisibility of much of the evidence base. In light of this, close monitoring of response and side effects is recommended as people with personality disorder may experience atypical effects with psychotropic medication.

For example, increased emotional dysregulation, dysphoria and parasuicidal phenomena occur not infrequently when SSRIs are prescribed to individuals with borderline personality disorder. It is recommended that treatment for co-occurring mental illness takes into account personality factors. If personality factors are not addressed as part of the overall treatment plan, progress may be slower. Consideration should be given to prioritising treatment of personality factors where appropriate, for example, when traits of rigidity and perfectionism predispose to recurrent depressive episodes.