Dosing guide for children between 12 and 29.9kg

Use diamorphine 720mcg/spray.

Weight of child Approx age No. of sprays Total dose delivered
12-17.9kg 2-5 years 2 1.44mg
18-23.9kg 5-8 years 3 2.16mg
24-29.9kg 8-10 years 4 2.88mg
  • Prime device twice before each administration.
  • Administer in alternate nostrils.
  • Patients should be monitored for at least 30 minutes following administration for signs of respiratory depression.

Dosing guide for children between 30 and 50kg

Use diamorphine 1600mcg/spray.

Weight of childApprox ageNo. of spraysTotal dose delivered
30-39.9kg10-14 years23.20mg
40-50kg14-15 years34.80mg (max dose)
  • Prime device twice before each administration.
  • Administer in alternate nostrils.
  • Patients should be monitored for at least 30 minutes following administration for signs of respiratory depression.

Reconstitution/preparation of solution

  1. Flip off protective cap.
  2. Tear off aluminium seal and pull out rubber bung.

3. Twist off seal from plastic tube containing diluent and squeeze contents into bottle.

4. Holding the bottle tightly, push nasal pump with tip attached onto glass bottle so it snaps in place.

5. Swirl bottle gently until powder is dissolved. Do not vigorously shake the bottle.

6. Write date of reconstitution and date for discarding (14 days after reconstitution) on label of the bottle.

7. Remove green safety clip and prime nasal spray by holding upright and actuating 8 times. Ensure dip tube remains in solution. Replace safety clip.

NB. Each time the tip is changed, the pump must be primes a further 2 times.

Priming/administration of solution

1. Remove green safety clip and prime twice into a sink wall or sharps bin.

2. Administer the necessary dose, alternating nostrils for each spray. Hold bottle upright ensuring dip tube remains in the solution.

3. Replace green safety clip and change the nasal tip.

4. Discard used nasal tip in sharps bin.

5. Monitor the patient for 30 minutes following administration.

 

 

Preparations available

Presentation

(Ayendi)

Total diamorphine in bottle as supplied Volume when reconstituted Single dose (dose per spray) Single spray liquid volume

Diamorphine 720mcg/actuation nasal spray bottle

72mg bottle

72mg

5ml (14.4mg/ml)

 

0.72mg 0.05ml

Diamorphine 720mcg/actuation nasal spray bottle

144mg bottle

144mg

10ml (14.4mg/ml)

0.72mg 0.05ml

Diamorphine 1600mcg/actuation nasal spray bottle

160mg bottle

160mg 5ml (32mg/ml) 1.6mg 0.05ml
Diamorphine 1600mcg/actuation nasal spray bottle 320mg

10ml (32mg/ml) 

1.6mg 0.05ml