Treatment of Depression Pathway

Warning

Objectives

Depression as diagnosed by ICD-11 criteria can present as mild, moderate and severe. There are different treatment options (medication and non-medication) appropriate for the different levels of severity.

The Scottish Borders Mental Health Services Integrated Care Pathway (available at mentalhealthpathway_doc_19-2-.pdf (scot.nhs.uk)) describes the different levels of mental health support available in NHS Borders. These range from self help websites, primary care to secondary care support and, where clinically appropriate, admission to the psychiatry unit.

The pathway and algorithm detail non-medication and medication options that should be optimised in the treatment of moderate depression before referral to secondary care.

NHS24 funds the choice and medication website on behalf of NHS Scotland. This website contains helpful drug and disease specific information for mental health conditions, as well as patient information leaflets on each medication listed: https://www.choiceandmedication.org/nhs24

Additional information from the above site is also available, with examples below:

Treatment of Depression Pathway

 

Psychological and Community Therapy

SPRING Social Prescribing available at: Health in Mind | Social Prescribing in the Scottish Borders (health-in-mind.org.uk)

NHS Borders Wellbeing Hub available at: nhsborders.scot.nhs.uk/patients-and-visitors/our-services/children-young-peoples-services-directory/health-improvement-team/mental-health-and-wellbeing/

RENEW Psychology Primary Care Services available via GP referral through SCI Gateway for moderate depression and anxiety.

Treatment of Depression Algorithm

 

Prescribing Notes & Choice of Alternative Antidepressant

Prescribing notes:

  • Trials of antidepressants must last at least 4 weeks (6 weeks in the elderly) at a dose approximately mid way between starting and maximum dose.
  • If treatment fails the diagnosis should be regularly review.
  • Doses should be increased/reduced in intervals of at least 1 week
  • Please check the additional information available in the East Region Formulary
Alternative Antidepressant Helpful in patient group Caution in patient group
Sertraline Recent cardiovascular events/ acts on serotonin only Risk of hyponatraemia in elderly
Citalopram Helpful if fluoxetine has been ineffective and only moderate depression / Acts on serotonin only Risk of Qtc prolongation: avoid if other risk factors for QTc prolongation (cardiovascular disease, other QTc prolonging medications)/ risk of hyponatraemia in elderly
Mirtazapine Patients with problems sleeping, underweight, lacking appetite, elderly patients / dual action on noradrenalin and serotonin Obesity/concerned with weight gain, patients who need to be up early
Venlafaxine Patients who lack motivation and struggle to get up in the mornings/more severe depressive symptoms/ dual action on serotonin and noradrenalin Hypertension, cardiovascular disease, some elderly patients, significant overdose risk

 

 

 

 

 

 

Prescribing Antidepressants in Pregnancy

Once indication to prescribe has been established, unless other considerations (such as prior response to an alternative SSRI), sertraline is a suitable first line treatment.

  • If insufficient response to sertraline, high risk patient, symptoms of severe depression – refer to referral pathways for pregnant and postnatal patients.

Information on antidepressants in pregnancy should be provided to the patient:

Editorial Information

Last reviewed: 01/02/2024

Next review date: 28/02/2026

Author(s): Richardson-Read S.

Version: MH010/03

Author email(s): segdae.richardson-read@nhs.scot.

Approved By: Area Drugs and Therapeutic Committee

Reviewer name(s): Richardson-Read S.