When prescribing for a women/birth parent in the perinatal period the potential for harm to the fetus and the breastfed infant must be carefully balanced with the potential harm to the mother/birthing parent and fetus or infant if the mother/birthing parent remains untreated.
Involve the women/birthing parent, and their family (where appropriate), in all decisions about treatment, including an individualised assessment of benefit versus risk.
Ensure that information is provided in plain language.
Take into consideration factors that may support relapse prevention or potential barriers to care, including stigma, and plan accordingly.
Provide information on:
- potential benefits of psychological interventions and pharmacological treatment
- the possible consequences of no treatment
- the possible harms associated with treatment
- what might happen if treatment is changed or stopped, particularly if pharmacological treatments are stopped abruptly.
Ensure there is a clear rationale for drug treatment, in keeping with relevant guidance and considering the differing risks of relapse with different illnesses.
Up-to-date safety alerts are available from the Medicines and Healthcare products Regulatory Agency - GOV.UK (www.gov.uk), and the UK Drugs in Lactation Advisory Service (UKDILAS).
See the full guideline for more information.
When prescribing medication during pregnancy or breastfeeding the following principles should be applied:
Discuss the potential risks and benefits of pharmacological treatment in each individual case with the woman/birthing parent and, where possible, their significant other(s), if consent is given to do so. Document the discussion.
Ideally, treatment with psychoactive medications during pregnancy involves close liaison between a treating psychiatrist or where appropriate the woman/birthing parent’s GP, and their maternity care provider(s). In more complex cases, it is advisable to seek a second opinion from a perinatal psychiatrist and other relevant members of the multidisciplinary team if needed, such as a pharmacist, neonatologist, or non-medical prescribers.
Risk of relapse:
Ensure that women/birthing parents are aware of the risks of relapse associated with stopping or changing medication and that, if a medication is ceased, this needs to be done gradually and with advice from the treating clinician.
Plan for pharmacological review in the early postpartum period for women/birthing parents who cease psychotropic medications during pregnancy.
Infant feeding preference:
Discuss treatment (medication and psychological) options that would enable a woman/birthing parent to breastfeed if they wish to and support those who choose not to breastfeed.
Fetal and neonatal monitoring:
When exposure to psychoactive medications has occurred in the first trimester (especially with anticonvulsant exposures) pay particular attention to the 11–14 week or 18–20 week ultrasound because of the increased risk of major malformation.
Consider that infants exposed to medication in pregnancy may be at risk of neonatal adaptation syndrome and may require additional monitoring after birth. Monitoring should be individualised and considered as part of multidisciplinary birth planning taking into consideration the medication dose, polypharmacy, infant feeding and infant vulnerability such as risk of preterm delivery, low birth weight and any obstetric complications.
Advise women/birthing parents against sleeping in bed with their infant, particularly if taking sedative drugs. Parents should be encouraged to follow safe sleep advice published by the Scottish Government,109 .