Intrahepatic Cholestasis of Pregnancy (ICP) or Obstetric Cholestasis (OC) (1137)
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Prevalence is influenced by genetic and environmental aspects.
In the UK ICP affects 7:1000 pregnancies – it is more common in Indian – Asian or Pakistani – Asian women where it affects 12-15:1000.
It is characterised by the presence of an itch with no visible rash and raised bile acid concentration of 19 micro mol/L or more.
The onset of symptoms is most common in the 3rd trimester but can be earlier in pregnancy.
Important points to remember:
- Alternative diagnosis (such as pre eclampsia) should always be considered before a diagnosis of ICP is made
- It is possible for other conditions to co-exist
- Pruritis and raised bile acid concentrations should return to normal after birth (persistently elevated levels may point to other diagnosis such as non alcoholic fatty liver)
- Around 25% of pregnant women develop itching – the majority of these do not have and do not develop ICP