Frequency of U+E Monitoring and Osmotic Demyelination Syndrome

ODS

Risk factors for Osmotic Demyelination Syndrome (ODS)

  • Serum sodium at presentation. ODS is rare with serum sodium >120 at presentation out with the context of diabetes insipidus or post liver-transplant. 
  • Duration of hyponatraemia. Recent onset (48 hours) onset of hyponatraemia confers a low risk of ODS. Chronic hyponatraemia should be assumed where duration is unknown.
  • Rate of correction. A rise of more than 10 mmol in 24 hours should be avoided. If this occurs or is likely to occur, then endocrinology should be involved. Polyuria is an early sign of rapid correction and should prompt early check of U&Es.
  • Hypokalaemia.
  • Liver disease.
  • Alcohol excess.
  • Malnutrition.

Frequency of U+E monitoring

  • Patients at high risk of ODS will require frequent (e.g. 4-hourly) monitoring of serum sodium and hourly urine volumes.
  • UEs should also be checked immediately after infusion of hypertonic saline.
  • Severely unwell or high-risk patients may require more frequent monitoring in a critical care setting.
  • In stable patients with asymptomatic chronic hyponatraemia BD U&Es may be sufficient.