Alternative diagnoses in adults
This content is from the BTS/SIGN British guideline on the management of asthma (SIGN 158), 2019.
Clinical clue | Possible diagnosis |
Without airflow obstruction | |
Predominant cough without lung function abnormalities | Chronic cough syndromes; pertussis |
Prominent dizziness, light headedness, peripheral tingling | Dysfunctional breathing |
Recurrent severe ‘asthma attacks’ without objective confirmatory evidence | Vocal chord dysfunction |
Predominant nasal symptoms without lung function abnormalities | Rhinitis |
Postural and food-related symptoms, predominant cough | Gastro-oesophageal reflux |
Orthopnoea, paroxysmal nocturnal dyspnoea, peripheral oedema, pre-existing cardiac disease | Cardiac failure |
Crackles in auscultation | Pulmonary fibrosis |
With airflow obstruction | |
Significant smoking history (ie, >30 pack-years), age of onset >35 years | COPD |
Chronic productive cough in the absence of wheeze or breathlessness |
Bronchiectasis*; inhaled foreign body*; obliterative bronchiolitis; large airway stenosis |
New onset in smoker, systemic symptoms, weight loss, haemoptysis | Lung cancer*; sarcoidosis* |
*may also be associated with non-obstructive spirometry