Sepsis of Unknown Source and Systemically Unwell (H@H)
Length of treatment: 5 days
Investigations:
Send blood cultures
If patient has urinary symptoms or febrile and unable to give a history send urine for culture where possible
If patient has respiratory symptoms consider a viral throat swab
Amoxicillin 1g orally every 8 hours
PLUS
Gentamicin intravenous as per NHS Lothian online calculator
PLUS
Metronidazole 400mg orally every 8 hours only if concerns regarding intra-abdominal
source of infection.
OR (Penicillin allergy)
Co-trimoxazole 960mg orally every 12 hours
(see Appendix 1) for dose reduction in renal impairment)
PLUS
Gentamicin intravenous as per NHS Lothian online calculator
PLUS
Metronidazole 400mg orally every 8 hours only if concerns regarding intra-abdominal
source of infection.
If after 48 hours the patient is responding and no positive culture results complete treatment with either amoxicillin or co-trimoxazole.
If patient is not responding then discuss with MoE/consultant from H@H service in the first instance, then seek advice from an infection specialist and consider whether continuation of antibiotics is appropriate