Example bug-drug combinations

Some examples of bug-drug combinations in practice are listed below:

 

Organism

Antibiotic

Result

High dose regime

Pseudomonas aeruginosa

Ciprofloxacin

I

750mg oral every 12 hours
400mg IV every 8 hours       

Pseudomonas aeruginosa

Piperacillin/tazobactam

I

4.5g IV every 6 hours

Staphylococcus aureus

Ciprofloxacin

I

750mg oral every 12 hours
400mg IV every 8 hours

Stenotrophomonas maltophilia

Co-trimoxazole

I

1440mg  oral/IV every 12 hours

Candida glabrata

Fluconazole

I

800mg oral/IV once daily 

Escherichia coli

Temocillin

I

2g IV every 8 hours

Haemophilus influenzae^

Amoxicillin

I

1g oral every 8 hours

Haemophilus influenzae^

Co-amoxiclav

I

Co-amoxiclav 625mg oral every 8 hours

+ Amoxicillin 500mg oral every 8 hours

^High dose regime applies to oral route only