Example bug-drug combinations
Some examples of bug-drug combinations in practice are listed below:
Organism |
Antibiotic |
Result |
High dose regime |
Pseudomonas aeruginosa |
Ciprofloxacin |
I |
750mg oral every 12 hours |
Pseudomonas aeruginosa |
Piperacillin/tazobactam |
I |
4.5g IV every 6 hours |
Staphylococcus aureus |
Ciprofloxacin |
I |
750mg oral every 12 hours |
Stenotrophomonas maltophilia |
Co-trimoxazole |
I |
1440mg oral/IV every 12 hours |
Candida glabrata |
Fluconazole |
I |
800mg oral/IV once daily |
Escherichia coli |
Temocillin |
I |
2g IV every 8 hours |
Haemophilus influenzae^ |
Amoxicillin |
I |
1g oral every 8 hours |
Haemophilus influenzae^ |
Co-amoxiclav |
I |
Co-amoxiclav 625mg oral every 8 hours + Amoxicillin 500mg oral every 8 hours |
^High dose regime applies to oral route only