See separate guidance for severe pneumonia in the frail elderly to avoid harms of 4C antibiotics.
Required investigations
- CXR
- Blood cultures
- Viral throat swab if being admitted (swab throat and nose at same time with single swab, send in viral transport medium); TRAK as 'Resp Virus Screen'
- Sputum for culture; TRAK as 'C&S-Respiratory (Routine Bacteriology)'
- Sputum for atypicals; TRAK as 'Respiratory Sputum (Inc Atypicals)
- Do not routinely send urine for Legionella urinary antigen. If patient unable to produce sputum, send urine for Legionella antigen (Document on request form “CAP CURB 3-5/severe, unable to produce sputum”) TRAK as 'Legionella Urinary Ag Profile'
Antibiotic Recommendation
Recommended total duration: 5 days (total duration = IV + oral)
Recommended Antibiotic |
Co-amoxiclav 1.2g every 8 hours IV
PLUS
Clarithromycin 500mg every 12 hours orally (IV only if oral route unavailable).
Risk of phlebitis with IV Clarithromycin. Oral formulation has excellent pulmonary tissue penetration and is as effective as IV for chest infections.
|
Penicillin allergy |
Vancomycin (use NHS Lothian Calculator located on AMT intranet page, choose trough levels 10-15 mg/L)
PLUS
Ciprofloxacin 500mg every 12 hours orally (if oral route unavailable: 400mg every 12 hours IV)
Avoid fluoroquinolones if taking steroids and the elderly.
Review MHRA Quinolone Warning before prescribing.
|
DO NOT ADD CLARITHROMYCIN IF CIPROFLOXACIN USED AS BOTH COVER ATYPICALS (SEE SECTION BELOW), AS DOES DOXYCYCLINE.
IV-to-ORAL switch |
Co-amoxiclav 625mg every 8 hours orally
Consider need for ongoing atypical pneumonia cover see atypical pneumonia section below.
|
Penicillin allergy |
Doxycycline 200mg on first day and then 100mg daily orally |
Notes
Stop antibiotic treatment after 5 days unless
- microbiological results suggest a longer course is needed or
- the patient is not clinically stable (fever in past 48 hours or more than 1 sign of clinical instability [systolic blood pressure <90 mmHg, heart rate >100/minute, respiratory rate >24/minute, arterial oxygen saturation <90% or PaO2 <60 mmHg in room air]).
In all patients consider:
- Repeat CXR in 6 weeks for all those with consolidation on CXR
- Smoking cessation advice
- Influenza/pneumococcal vaccination for those >65 years or with chronic illness.