3.1 Review medication affecting renal function (e.g. NSAIDs, diuretics, ACE-inhibitors) and consider stopping or withholding.
3.2 Check U+E in 3-4 days (note that it can take up to 7 days for the full effects of bisphosphonate therapy to manifest). If corrected serum calcium has not returned to reference range, discuss future management with the consultant.
3.3 If consultant recommends rescue therapy, administer zoledronate 8mg over 60 minutes.
3.4 When using pamidronate in renal impairment:
3.4.1 Adjust dose according to the level of the corrected calcium as follows:
Calcium <3.0: 30mg
Calcium 3-3.5: 60mg
Calcium >3.5: 90mg
3.4.2 If GFR <30ml/min then administer pamidronate at a rate of 20mg/hour (in at least 500ml 0.9% sodium chloride. Volume will depend on renal function)
3.5 Please also refer to ‘Bisphosphonates in Myeloma’ on the haematology intranet site for further information on the use of bisphosphonates in myeloma.
3.6 Certain patients may require long-term bisphosphonate therapy to prevent recurrence of hypercalcaemia – discuss with consultant if this is unclear.