Warning

Drug-induced hyponatraemia: potential causes 

Anti-cancer agents 

  • Vincristine 
  • Vinblastine 
  • Cisplatin 
  • Carboplastin
  • Cyclophosphomide 
  • Melphalan 
  • Ifosfamide 

Anti-depressants 

  • Tricyclics 
  • SSRIs 
  • Monoamine oxidase inhibitors 

Anti-epileptics 

  • Carbamazepine 
  • Oxycarbamazepine 
  • Sodium valproate 

Anti-hypertensives 

  • ACE inhibitors
  • Amlodipine 

Anti-psychotics 

  • Phenothiazine
  • Butyrophenones 

Diuretics 

  • Thiazides 
  • Amiloride 
  • Spironolactone/Eplerenone 
  • Loop diuretics 

Proton pump inhibitors 

  • Omeprazole 

 

References

  • Grant P et al. “The diagnosis and management of inpatient hyponatraemia and SIADH,” Eur J Clin Invest 2015; 45(8) 888-894

ABBREVIATIONS

Abbreviation  Meaning 
BD  twice daily 
BP  blood pressure 
CNS  central nervous system 
IV  intravenous 
JVP  jugular venous pressure 
potassium 
LVF  left ventricular failure 
Na  sodium 
OD  once daily 
SIADH  syndrome of inappropriate antidiuretic hormone secretion

Editorial Information

Last reviewed: 23/06/2020

Next review date: 30/06/2023

Author(s): Endocrinology department.

Version: 2

Approved By: TAM Subgroup of the ADTC

Reviewer name(s): Dr D MacFarlane, Consultant Physician , N Cantley , L Lufty , C Vincent .

Document Id: TAM293