Non-gonococcal urethritis (Antimicrobial)

  • Cases of suspected NGU should be tested for Chlamydia, gonorrhoea and Mycoplasma Genitalium. 
  • Full STI screening to also include HIV and syphilis is recommended.
  • It is recommended that patients with suspected NGU are referred to Sexual Health
  • Those with recurrent or persistent symptoms should be referred to Sexual Health.

Patient information is available here:

Drug details

First episode. Test for C. trachomatis and M. genitalium.

Doxycycline 100mg twice daily


7 days

OR Azithromycin 1g stat then 500mg once daily for 2 more doses

3 days (2g) in total

Levofloxacin should only be used if both doxycycline and azithromycin are not suitable.
Seek advice for recurrent or persistent infection.

OR Levofloxacin 500mg once daily (see BNF warnings and MHRA Drug Safety Alert (updated 22 January 2024))

7 days

Editorial Information

Last reviewed: 27/02/2023

Next review date: 27/02/2026

Author(s): Antimicrobial Management Team.

Approved By: TAM Subgroup of ADTC

Reviewer name(s): Alison Macdonald, Area Antimicrobial Pharmacist.

Document Id: AMT127