Consider carbocisteine in patients with COPD and chronic cough productive of sputum. Continue if there is symptomatic improvement. If there is no benefit after a 4-week trial, stop therapy. Nebulised sodium chloride 0·9% solution has no place as a mucolytic in either COPD or asthma.

CARBOCISTEINE

Important: Therapy notes

Important: Formulation and dosage details

Formulation:

Capsules 375mg

Dosage:

750mg 3 times daily initially, then 375mg 4 times daily as condition improves.

Important: Formulation and dosage details

Formulation:

Oral liquid 250mg/5mL

Dosage:

750mg 3 times daily initially, then 375mg 4 times daily as condition improves.

DORNASE ALFA

Important: Therapy notes

Important: Formulation and dosage details

Formulation:

Nebuliser solution 2·5mg (2500 units)/2·5mL (specialist initiation)

ACETYLCYSTEINE

Important: Therapy notes

Important: Formulation and dosage details

Formulation:

Effervescent tablets 600mg

Dosage:

If there is no benefit after a 4-week trial, stop therapy.

Editorial Information

Document Id: F364