Compound preparations with corticosteroid and long acting beta2 agonist (ICS/LABA) in COPD (Formulary)

Note: Review the need for inhaled steroids in patients with COPD if an episode of pneumonia has occurred. High doses of inhaled corticosteroid have been associated with lower respiratory tract infections, including pneumonia, in older patients with COPD.

Please consider if a steroid emergency card needs to be given to the patient alongside the traditional steroid treatment card.  This is to support the timely recognition and treatment of potential adrenal crisis and is suitable for some patients on oral, inhaled, topical or rectal steroids.  For more information, including which patients should receive the card, see HIS for details.  Steroid emergency cards have been distributed to, hospitals, GP surgeries and community pharmacies. Primary care can order replacement cards from 01463 706886.• inhaled corticosteroids, in combination with a long-acting bronchodilator, should be prescribed for patients with an FEV1 of 50% or less of predicted, who are having 2 or more exacerbations requiring treatment with antibiotics or oral corticosteroid in a 12-month period. Refer to NICE guidance on the management of COPD in adults in primary and secondary care.
• fluticasone with vilanterol (Relvar® Ellipta® 92/22) is cost-effective and offers the advantage of once-daily dosing.
• in patients with moderate to very severe COPD who are unsuitable for inhaled corticosteroid and in those who remain breathless or have exacerbations despite taking long-acting beta agonist plus inhaled corticosteroid consider a combination bronchodilator inhaler (LAMA/LABA).

See Peri-operative guidelines for patients with or at risk of adrenal insufficiency.

FLUTICASONE WITH VILANTEROL (Relvar Ellipta®▼) - (First line)

Important: Therapy notes

Important: Formulation and dosage details

Formulation:

PREFERRED: Dry Powder Inhaler (DPI) (Inhalation powder)These are more environmentally friendly than MDIs and should be considered first line providing that the patient shows good inhaler technique with the chosen device.

  • Dry powder inhaler 92/22 (in micrograms)

Dosage:

COPD, by inhalation of powder, 92/22 inhaler, 1 puff once daily.

BECLOMETASONE WITH FORMOTEROL

Important: Therapy notes

Important: Formulation and dosage details

Formulation:

PREFERRED: Dry Powder Inhaler (DPI) (Inhalation powder)These are more environmentally friendly than MDIs and should be considered first line providing that the patient shows good inhaler technique with the chosen device.

  • Dry powder inhaler (Fostair® NEXThaler) 100/6 (in micrograms)

Dosage:

COPD, by inhalation of powder (Fostair® NEXThaler), 2 puffs twice daily

Important: Formulation and dosage details

Formulation:

ALTERNATIVE: Metered dose inhalers (MDI) (Pressurised inhalation)To be considered in the small proportion of patients who are unable to use a DPI.

  • Aerosol inhalation (Fostair®) 100/6 (in micrograms)

Dosage:

COPD, by aerosol inhalation (Fostair®), 2 puffs twice daily.

FLUTICASONE WITH SALMETEROL (Seretide® Accuhaler®)

Important: Therapy notes

Important: Formulation and dosage details

Formulation:

PREFERRED: Dry Powder Inhaler (DPI) (Inhalation powder)These are more environmentally friendly than MDIs and should be considered first line providing that the patient shows good inhaler technique with the chosen device.

  • Dry powder for inhalation (Seretide® Accuhaler®) disk containing blisters of 500/50 (in micrograms)/blister

Dosage:

COPD, by inhalation of powder 500/50/blister, 1 blister twice daily.

FLUTICASONE FUROATE/UMECLIDINIUM/VILANTEROL (Trelegy Ellipta)

Important: Therapy notes

Important: Formulation and dosage details

Formulation:

PREFERRED: Dry Powder Inhaler (DPI) (Inhalation powder)These are more environmentally friendly than MDIs and should be considered first line providing that the patient shows good inhaler technique with the chosen device.

  • (as trifenatate) 92mcg/55mcg/22mcg inhalation powder

Dosage:

See step-down ICS guidance in COPD.

As per SMC 1303/18: maintenance treatment in adult patients with moderate to severe chronic
obstructive pulmonary disease (COPD) who are not adequately treated by a combination of an
inhaled corticosteroid and a long-acting β2-agonist.
SMC restriction: in patients with severe COPD (forced expiratory volume in one second [FEV1]
<50% predicted normal). 

BECLOMETASONE/FORMOTEROL/GLYCOPYRRONIUM (Trimbow)

Important: Therapy notes

Important: Formulation and dosage details

Formulation:

ALTERNATIVE: Metered dose inhalers (MDI) (Pressurised inhalation)To be considered in the small proportion of patients who are unable to use a DPI.

  • 87 micrograms/5 micrograms/9 micrograms metered dose inhaler

Dosage:

See step-down ICS guidance in COPD.

See SMC 1274/17: Maintenance treatment in adult patients with moderate to severe chronic obstructive pulmonary disease (COPD) who are not adequately treated by a combination of an inhaled corticosteroid and a long-acting beta2-agonist.
SMC restriction: severe COPD (forced expiratory volume in one second less than 50% predicted normal).

FORMOTEROL FUMARATE WITH GLYCOPYRRONIUM AND BUDESONIDE

Important: Therapy notes

Important: Formulation and dosage details

Formulation:

ALTERNATIVE: Metered dose inhalers (MDI) (Pressurised inhalation)

To be considered in the small proportion of patients who are unable to use a DPI.

Pressurised inhalation, suspension (Trixeo® Aerosphere) 5microgram /7.2microgram /160microgram /dose

Dosage:

As per SMC2321: maintenance treatment in adult patients with moderate to severe chronic obstructive pulmonary disease (COPD) who are not adequately treated by a combination of an inhaled corticosteroid and a long-acting beta2-agonist, or combination of a long-acting beta2-agonist and a long-acting muscarinic antagonist.
SMC restriction: in patients with severe COPD (forced expiratory volume in one second [FEV1] less than 50% predicted normal).

Editorial Information

Document Id: F355