Important: Therapy notes
- Refer to guidance in respiratory handbook on Ward 7a, Raigmore Hospital.
- For use in the management of hyper-acute stroke refer to Stable angina, acute coronary syndromes and fibrinolysis.
Important: Formulation and dosage details
Formulation:
Injection 10mg (5·8 million units/vial), 50mg (29 million units/vial) (s)
Dosage:
By intravenous injection, for the treatment of pulmonary embolism following specialist advice: 10mg over 1 to 2 minutes, followed by intravenous infusion of 90mg over 2 hours; max 1·5mg/kg in patients less than 65kg.
By intrapleural injection, for the treatment of empyema off-label: 10mg every 12 hours for three days (followed by 5mg intrapleural dornase alfa (Mucolytics) off-label one hour after each alteplase injection and subsequent free drainage).