Other respiratory emergencies (Formulary)

ALTEPLASE

Important: Therapy notes

Important: Formulation and dosage details

Formulation:

Injection 10mg (5·8 million units/vial), 50mg (29 million units/vial) (s)

Dosage:

By intravenous injection, for the treatment of pulmonary embolism following specialist advice: 10mg over 1 to 2 minutes, followed by intravenous infusion of 90mg over 2 hours; max 1·5mg/kg in patients less than 65kg.

By intrapleural injection, for the treatment of empyema off-label: 10mg every 12 hours for three days (followed by 5mg intrapleural dornase alfa (Mucolytics) off-label one hour after each alteplase injection and subsequent free drainage). 

Editorial Information

Document Id: F361