Phosphate-binding agents (Formulary)

CALCIUM CARBONATE

Important: Therapy notes

Important: Formulation and dosage details

Formulation:

Tablets (Calcichew®) 1·25 grams (calcium 500mg or 12·5mmol/tablet)

Dosage:

Initially 1 to 2 tablets 3 times daily with meals, then adjusted according to plasma-phosphate concentration.

CALCIUM ACETATE

Important: Therapy notes

Tablets can be broken to aid swallowing, but not chewed (bitter taste).

Important: Formulation and dosage details

Formulation:

Tablets (Phosex®) 1 gram (calcium 250mg or 6·2mmol/tablet)

Dosage:

Initially 1 tablet 3 times daily with meals, then adjusted according to plasma phosphate concentration. 

LANTHANUM

Important: Therapy notes

Important: Formulation and dosage details

Formulation:

Tablets 500mg, 750mg, 1 gram

Dosage:

Initially 750mg daily in divided doses with meals or immediately after meals, then adjusted according to plasma phosphate concentration every 2 to 3 weeks.

Important: Formulation and dosage details

Formulation:

Powders 750mg, 1 gram

SEVELAMER

Important: Therapy notes

Important: Formulation and dosage details

Formulation:

Tablets 800mg

Dosage:

Initially 1 to 2 tablets 3 times daily with meals, then adjusted according to plasma-phosphate concentration.

SUCROFERRIC OXYHYDROXIDE

Important: Therapy notes

Important: Formulation and dosage details

Formulation:

Chewable tablets 500mg

Dosage:

Initially 1·5 grams daily in 3 divided doses, dose to be taken with meals, then adjusted in steps of 500mg every 2 to 4 weeks, dose adjusted according to serum-phosphate concentration

Maintenance 1·5 to 2 grams daily in divided doses, maximum 3 grams per day.

Editorial Information

Document Id: F313