Antifungal drugs for specialist use only (Formulary)

Use only in accordance with protocols or on advice of Microbiology, Infectious Diseases or appropriate Consultant Specialist.

AMPHOTERICIN B

Important: Therapy notes

MHRA advice: Liposomal and lipid-complex formulations: name change to reduce medication errors (July 2020) (www.gov.uk).
MHRA advice: Parenteral amphotericin B: reminder of risk of potentially fatal adverse reaction if formulations confused (July 2018) (www.gov.uk).

Important: Formulation and dosage details

Formulation:

Infusion 50mg (Fungizone®) (Protected antibiotic to be prescribed on the advice of an infection specialist only) 

Important: Formulation and dosage details

Formulation:

Powder for dispersion for infusion 50mg (AmBisome Liposomal®) (Protected antibiotic to be prescribed on the advice of an infection specialist only) 

ANIDULAFUNGIN

Important: Therapy notes

Important: Formulation and dosage details

Formulation:

Infusion 100mg (Protected antibiotic to be prescribed on the advice of an infection specialist only) 

CASPOFUNGIN

Important: Therapy notes

Important: Formulation and dosage details

Formulation:

Infusion 50mg, 70mg (Protected antibiotic to be prescribed on the advice of an infection specialist only) 

FLUCYTOSINE

Important: Therapy notes

MHRA alert: Flucytosine (Ancotil): new contraindication in patients with DPD deficiency (October 2020) (www.gov.uk).

Important: Formulation and dosage details

Formulation:

Infusion 2·5 grams/250mL (Protected antibiotic to be prescribed on the advice of an infection specialist only) 

POSACONAZOLE

Important: Therapy notes

MHRA advice: Posaconazole (Noxafil): tablets and oral suspension are not directly interchangeable (September 2016) (www.gov.uk).

  • Use tablets in preference to the oral suspension. 
  • Due to differences in the dosing of each formulation the tablets and oral suspension are not interchangeable.

Important: Formulation and dosage details

Formulation:

Tablets 100mg (Protected antibiotic to be prescribed on the advice of an infection specialist only) 

Important: Formulation and dosage details

Formulation:

Oral suspension 200mg/5mL (Protected antibiotic to be prescribed on the advice of an infection specialist only) 

VORICONAZOLE

Important: Therapy notes

MHRA advice: Voriconazole: reminder of risk of liver toxicity, phototoxicity, and squamous cell carcinoma (December 2014) (www.gov.uk).

Risk minimisation materials

Important: Formulation and dosage details

Formulation:

Tablets 50mg, 200mg (Protected antibiotic to be prescribed on the advice of an infection specialist only) 

Important: Formulation and dosage details

Formulation:

Oral suspension 200mg/5mL (Protected antibiotic to be prescribed on the advice of an infection specialist only) 

Important: Formulation and dosage details

Formulation:

Intravenous infusion 200mg (Protected antibiotic to be prescribed on the advice of an infection specialist only) 

Editorial Information

Document Id: F275