Glucose-dependent insulinotropic polypeptide (GIP) receptor & Glucagon-like peptide-1 (GLP-1) receptor agonists (Formulary)

MHRA advice: GLP-1 receptor agonists: reports of diabetic ketoacidosis when concomitant insulin was rapidly reduced or discontinued (June 2019) (www.gov.uk).

Refer to protocol for use of GLP-1 analogues.

Important: Supplementary notes

Currently GIP (glucose-dependent insulinotropic polypeptide) receptor and GLP-1 (glucagon-like peptide-1) receptor agonists are NOT recommended to be prescribed in NHS Highland for weight management. Further information can be seen in the Pink One newsletter (NHS Highland intranet access required). 

Statement about medications to support weight management in NHS Highland.

The following medications have been approved by the Scottish Medicines Consortium (SMC) to support weight management in NHS Scotland.

Liraglutide (Saxenda®)

Due to national shortages, NHS Highland is unable to start anyone on this medication.

Saxenda® is NOT recommended to be prescribed in NHS Highland for weight management.

Semaglutide (Wegovy®)

NHS Highland has accepted a formulary submission for this medication and it will become available once local clinical pathways are in place. A national Short Life Working Group has produced recommendations to support Scottish Health Boards develop local clinical pathways. This process is underway in NHS Highland.

Until these pathways have been developed, Wegovy® is NOT recommended to be prescribed in NHS Highland for weight management.

Tirzepatide (Mounjaro®)

There has been no request to add this medication to the Highland Formulary at this time. Once a clinical pathway has been set up for prescribing these medications, this will enable a formulary submission to be submitted and assessed.

Tirzepatide (Mounjaro®) is NOT recommended to be prescribed in NHS Highland for weight management.

See NHS Highland’s Healthy Weight Pathway

LIRAGLUTIDE - (First line)

Important: Therapy notes

First line once daily option.

MHRA advice: Ozempic (semaglutide) and Saxenda (liraglutide): vigilance required due to potentially harmful falsified products (November 2023) (www.gov.uk).


Important: Formulation and dosage details

Formulation:

Injection, pre-filled pen 18mg/3mL

SEMAGLUTIDE - (First line)

Important: Therapy notes

First line once weekly option.

MHRA advice: Ozempic (semaglutide) and Saxenda (liraglutide): vigilance required due to potentially harmful falsified products (November 2023) (www.gov.uk).


Important: Formulation and dosage details

Formulation:

Solution for injection, pre-filled pen (Ozempic) 0·25mg, 0·5mg and 1mg

Important: Formulation and dosage details

Formulation:

Tablets (Rybelsus) 3mg, 7mg and 14mg

Dosage:

Oral, once daily alternative to subcutaneous semaglutide - when subcutaneous route not suitable.

DULAGLUTIDE - (Second line)

Important: Therapy notes

Second line once weekly option.

Important: Formulation and dosage details

Formulation:

Injection, pre-filled pen 750 micrograms/0·5mL, 1·5mg/0·5mL 

TIRZEPATIDE - (Third line)

Important: Therapy notes

Caution. For full details see BNF and Manufacturer information

  • Tirzepatide delays gastric emptying, particularly following the first dose.  This has the potential to slow the rate of absorption of concomitant oral medicines.  The risk of a delayed effect should be considered for oral medicines where a rapid onset of action is important.  Monitor patients on oral medicines with a narrow therapeutic index, especially at the start of tirzepatide treatment and after dose increases.
  • Since reduced efficacy of oral contraceptives cannot be excluded, it is advised that female patients who are overweight or obese and using an oral contraceptive should add a barrier method of contraception or switch to a non-oral contraceptive method for the first 4 weeks of treatment, and for 4 weeks after each dose increase.
  • Discontinue treatment at least one month before planned pregnancy.

Important: Formulation and dosage details

Formulation:

KwikPen 2.5mg, 5mg, 7.5mg, 10mg, 12.5mg, 15mg solution for injection in prefilled pen (Restricted: Specialist recommendation only)

Dosage:

As per SMC2633: for the treatment of adults with insufficiently controlled type 2 diabetes mellitus as an adjunct to diet and exercise and in addition to other oral anti-diabetic medicines as an option when glucagon-like peptide-1 (GLP-1) receptor agonists would be considered.

Place in therapy:

  • Generally after a trial of GLP-1 receptor agonist (RA). This guidance is based on the lack of confirmed CV benefit at present.
  • As an alternative to GLP-1 RAs in the following instances:
    • Supply issue with existing GLP-RAs
    • Suboptimal glycaemia despite GLP-1 RA use
    • High risk individuals in where greater weight loss will have a positive benefit on obesity related complications e.g. young onset, Obstructive Sleep Apnoea etc.

Editorial Information

Last reviewed: 11/02/2021

Approved By: TAM Subgroup

Document Id: F175