Angiotensin-II receptor antagonists (Formulary: Cardiovascular)

Important: Formulation and dosage details

Formulation:

Tablets 2mg, 4mg, 8mg, 16mg, 32mg

Dosage:

Hypertension: initially 8mg (mild or moderate hepatic impairment, renal impairment or intravascular volume depletion 4mg, avoid in severe hepatic impairment), once daily increased if necessary at intervals of 4 weeks to maximum 32mg once daily; usual maintenance dose 8mg once daily.
Heart failure: initially 4mg once daily, increased at intervals of at least 2 weeks to ‘target’ dose of 32mg once daily or to maximum tolerated dose. Maximum dose 32mg once daily.

Important: Formulation and dosage details

Formulation:

Tablets 12·5mg, 25mg, 50mg, 100mg

Dosage:

Hypertension: initially 25mg then titrate as needed (older people over 75 years, moderate to severe renal impairment, intravascular volume depletion, initially 25mg once daily); increased to 100mg once daily if needed. 
Heart failure: initially 12·5mg once daily, increased at weekly intervals to maximum 150mg once daily if tolerated. 
Secondary prevention post-TIA or ischaemic stroke if intolerant of perindopril, initially 25mg once daily then titrate as needed.

Important: Formulation and dosage details

Formulation:

Capsules 40mg, 80mg, 160mg (specialist recommendation only)

Important: Formulation and dosage details

Formulation:

Tablets 40mg (specialist recommendation only)

Dosage:

Heart failure post-myocardial infarction: initially 20mg twice daily increased over several weeks to 160mg twice daily if tolerated.

Important: Formulation and dosage details

Formulation:

Tablets 75mg, 150mg, 300mg (specialist recommendation only)

Dosage:

Renal disease in hypertensive type 2 diabetes: initially 150mg once daily, increased if necessary to 300mg once daily.
In haemodialysis or in older people over 75 years, consider initial dose of 75mg once daily.