TAM (Treatments and Medicines) NHS Highland
Treatment of venous leg ulcers that have failed to heal after 3 months.
Pentoxifylline Shared Care Protocol (Formularies)
Warning
Pentoxifylline 400mg m/r tablets 
400mg three times daily for up to 6 months.
In patients with renal impairment (creatinine clearance below 30mL/min) a dose reduction by approximately 30% to 50% may be necessary, guided by individual tolerance.
Initiation of pentoxifylline by consultant or vascular specialist nurse
- to assess the patient and establish that pentoxifylline is an appropriate treatment
- to ensure that there are no contra-indications or significant drug interactions
- to ensure that the patient is fully informed about their treatment
- to notify the GP of the change of therapy
- to inform the GP via a clinic letter if any follow up is required.
Continuation of treatment - GP’s responsibilities
- continuation of prescription for up to 6 months
- to review patient according to follow-up plan in clinic letter
- reporting any adverse effects of treatment.
Medications with potential interactions with pentoxifylline include:
- non-steroidal anti-inflammatory drugs (NSAIDs): possible increased risk of bleeding when pentoxifylline given with NSAIDs
- theophylline – pentoxifylline increases plasma concentrations of theophylline.
Take tablets with or immediately after meals, and swallow whole with plenty of water.