The following is for opioid naïve patients and should be used as a baseline for non-opioid naïve patients
Drug |
Dose |
Route |
Times |
Paracetamol |
1g |
oral |
08.00, 12.00 18.00, 22.00 |
Dihydrocodeine |
30mg |
oral |
08.00, 12.00 18.00, 22.00 |
Dihydrocodeine |
30mg |
oral |
4 hourly as required for mild to moderate pain. Max 240mg daily in total, including regular. |
Oxcodone IR |
5mg |
oral |
2 hourly as required for severe pain. Dose may need to be adjusted as clinically indicated. Unlikely to be outside 2.5 to 10mg range. |
Laxido |
1 sachet |
oral |
08.00, 18.00 while on regular opioids |
Ondansetron |
4mg |
IV |
6 hourly as required for PONV. Max three times a day. |
Prochlorperazine |
3mg |
buccal |
As required for PONV. Max twice daily. |
- Pre-operative modified release opioids should be continued at the same dose in the peri-operative period.
- Opioid reduction should be considered post-operatively under the care of the primary care team and/or hospital pain team as appropriate
- Breakthrough strong opioids should be the same drug and dose as that used pre-operatively, OR oxycodone instant release (IR) at an appropriate dose (approximately one sixth of daily opioid dose, but no higher than 10mg until clinical effect observed).
- Modified-release opioids should NOT be initiated in the immediate post-operative period.
- NSAIDs are effective analgesics following arthroplasty surgery, however the use of aspirin 150mg daily for surgical thromoboprophylaxis increases the risks associated with their use.
- Use should be considered on a case by case basis, bearing in mind gastric, renal and cardiovascular side effects and risk. See NSAID guideline (see resources).
- If appropriate, either continue NSAID used pre-operatively, OR ibuprofen 400mg orally, three times a day, WITH lansoprazole 30mg orally, once daily for a maximum of five days.
Other essential components of the ERAS bundle include pre-operative analgesia, surgical and anaesthetic intra-operative analgesia, surgical venous thromboprophylaxis and non-pharmacological post-operative therapy including early mobilisation, cryotherapy and psychology. These are outside the scope of this guidance.