- Dietary history from birth.
- Exposure to sunlight (child and mother).
- Use of drugs and multivitamins.
- Motor development.
- Measure and accurately plot height and weight.
- Assess general nutritional status.
- Look for classical signs of rickets.
Clinical assessment
- Left wrist X-ray in children <3 years old, knee X-ray in children >3 years old.
- Serum urea, electrolytes, creatinine.
- Bone profile (Ca, Mg, Phosphate, Alkaline Phosphatase).
- Liver function tests.
- Full blood count.
- PTH.
- 25 Hydroxy Vitamin D.
The classical biochemical picture of vitamin D deficiency is:
- Calcium – Normal or low.
- Phosphate – Normal or low.
- Alkaline phosphatase – Raised.
- PTH – Normal or raised.
- 25 Hydroxy cholecalciferol (25OHCC) – Low.
- Deficiency – Less than 30nmol/L.
- Insufficiency – 30 to 50nmol/L.
- Sufficiency – Above 50nmol/L.