Re-evaluation of thyroid axis
This may be required if no cause has been identified for the hypothyroidism in the neonatal period and should be considered after the age of 3 years.
Re-evaluation should be considered in patients with a normally sited thyroid gland and / or those who have had no increase in thyroxine requirement since infancy.
This can consist of either:
- An initial reduction in thyroxine dose followed by monitoring of thyroid function and further reductions in thyroxine dose and monitoring of thyroid function if results remain normal, until thyroxine is discontinued
Discontinuation of thyroxine with thyroid function assessment in 4-6 weeks - If the TSH is elevated, hypothyroidism is confirmed, and treatment should be recommenced as soon as possible.
Re-evaluation is not indicated if there has been a rise in the TSH in the first year, if there is a genetic cause or if there is an abnormal gland on imaging.