Written instructions on how to give thyroxine should be available and supplied to the parents.

Levothyroxine tablets

  • Available as 12.5microgram, 25 microgram, 50 microgram, 75 microgram or 100 microgram strength.
  • The tablets should be crushed and mixed with a small volume (less than 5ml) of liquid (formula, expressed breast milk or boiled and cooled water).
  • If necessary, a tablet cutter for halving tablets should be supplied to the family.
  • The first dose should be given by parents under the supervision of a nurse of pharmacist.

SPEG does not recommend using any of the liquid forms of thyroxine which are available including syrups, solutions and suspensions.

Tablets have been used extensively and successfully in the management of congenital hypothyroidism and therefore SPEG recommends the use of tablets, in accordance with European Society for Paediatric Endocrinology guidelines (ESPE) (1). Tablets are also much cheaper to use than other preparations.