Definitions

Biofilm: a slime-enclosed community of bacterial colonies that is very difficult to eradicate even with the most powerful antibiotics or sterilising systems.37

Ecthyma: a pus forming, ulcerating and crusting inflammatory skin disease.38

Endotoxin: a toxin produced by certain bacteria and released upon destruction of the bacterial cells.39

Ex vivo: in an artificial environment outside a living organism.40

Furunculosis: a condition in which the patient suffers from recurrent episodes of boils.41

Hepatalgia: pain in the liver.42

Hidradenitis: inflammation of a sweat gland.43

Lytic: of or relating to lysis; the destruction of a living cell by disruption of its membrane.44

Paronychia: infection of the skin fold at the base or side of the nail.45

Pyoderma: a pus containing skin infection.46

Sycosis vulgaris: a chronic inflammation of the hair follicles, especially of the beard, characterised by eruption of pimples and nodules.47

Abbreviations

ARLG Antibacterial Resistance Leadership Group
CPI consumer price index
CS case studies
DFI diabetic foot infection
DFU diabetic foot ulcer
DNA deoxyribonucleic acid
ESKAPE Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baummannii, Pseudomonas aeruginosa, and Enterobacter species
FRI fracture-related infection
GMP Good Manufacturing Process
GRADE Grading of Recommendations, Assessment, Development and Evaluations
ICER incremental cost effectiveness ratio
LEA lower extremity amputation
MHRA Medicines and Healthcare Products Regulatory Authority
NA not applicable
NHS National Health Service
NICE National Institute of Health and Care Excellence
NR not reported
OBS observational trial
PFU plaque forming units
PJI periprosthetic joint infection
PSSRU Personal and Social Services Research Unit
PT phage therapy
QALY quality-adjusted life-year
RCT randomised controlled trial
SHTG Scottish Health Technologies Group
SoC standard of care