• Antibiotic choice should be directed by previous positive cultures - in the absence of previous positive sputum cultures, oral antibiotics to cover common respiratory pathogens are recommended, using local formulary guidance where available
  • Azithromycin 250mg three times a week is recommended for patients with four or more exacerbations in any 12-month period, usually started after advice from secondary care
  • Recommend six-month review of effectiveness of mucolytics