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Study population:

Postmenopausal women

a) For primary prevention average T-score was within 2 standard deviations of the mean for bone density

b) For secondary prevention women who had experienced previous vertebral compression fractures

Comments:

Age range 42-85 but >62 for secondary prevention.

These NNTs apply to the first 5 years of treatment only.

All patients received calcium and vitamin D

 

Outcome Duration NNT Annualised NNT
Rate of vertebral, non-vertebral or hip fractures (as below) over a 5 year period vertebral primary prevention 60 months (5 years)
Age NNT
65-69 148
70-74 123
75-79 67
80-84 97
85-89 89
90+ 47

 
Age NNT
65-69 740
70-74 615
75-79 335
80-84 485
85-89 445
90+ 235

 
Non-vertebral primary prevention 60 months (5 years)
Age NNT
65-69 104
70-74 67
75-79 59
80-84 42
85-89 32
90+ 12

 
Age NNT
65-69 520
70-74 335
75-79 295
80-84 210
85-89 160
90+ 60

 
Hip primary prevention 60 months (5 years)
Age NNT
65-69 23
70-74 118
75-79 50
80-84 27
85-89 11
90+ 9
Age NNT
65-69 118
70-74 590
75-79 250
80-84 135
85-89 55
90+ 45