Betablocker (Bisoprolol titrated to target dose of 10mg/day) vs placebo

Polypharmacy icon of two pills

Study population:

Patients with moderate to severe heart failure NYHA III-IV  LVEF ≤ 0.35 were enrolled

Comments:

Mean age of patients was 61 years, 83% of which were NHYA III.


Current treatment had to include a diuretic and an ACE inhibitor although other vasodilators were allowed if patients were intolerant of ACE inhibitors. 96% of patients were on ACE inhibitors.

 

Outcome Duration NNT Annualised NNT
Prevent one death (all cause)

1.3 years

(mean duration of follow-up)

18

24

References

CIBIS-II Investigators or Committees. The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II): a randomised trial. The Lancet. 1999; 353: 9-13.