Anticoagulants

Check for expired indications (e.g. temporary loss of mobility that has now resolved)

Need

Much more effective for stroke prevention in AF than antiplatelets

Effectiveness

CAUTION: Bleeding events. Avoid combinations of anticoagulants, antiplatelets, NSAIDs.

Safety

Ensure patient adherence to dosing/monitoring regimen

  • If patient is unfit for warfarin for cognitive reasons (NOACs may not be indicated either)

Adherence/Patient centeredness

Antiplatelets

NOTE: Antiplatelets are no longer indicated for primary prevention of CHD.

Aspirin plus clopidogrel indicated for a maximum of 12 months after ACS only.

Need

CAUTION: Bleeding events. Avoid combinations of anticoagulants, antiplatelets, NSAIDs.

  • Consider PPI in those with additional GI risk factors (consider lansoprazole or pantoprazole in preference to (es)omeprazole in patients taking clopidogrel)

Safety

Consider anti-platelets as part of secondary prevention strategy after CVD events.
First line anti-platelet for secondary stroke prevention is clopidogrel (rather than dipyridamole)

Effectiveness

Diuretics

Usually essential for symptom control in heart failure

Note: Not indicated for dependent ankle oedema (consider medication causes, e.g. CCBs

Need

CAUTION: AKI and electrolyte disturbances.

Safety

Advise patient to stop during intercurrent illness (See Sick Day Rule Cards); is U&E monitoring robust?

Adherence/Patient centeredness

Spironolactone

CAUTION: Hyperkalaemia. Risk factors include: CKD (CI if eGFR<30ml/min), dose >25mg/d, co-treatment with ACEI/ARBs, amiloride, triamterene, potassium supplements.

Safety

Digoxin

CAUTION: Toxicity! Risk factors are: CKD, dose>125micrograms daily, poor adherence, hypokalaemia, drug-drug interactions.

Safety

Peripheral vasodilators

Rarely effective; rarely indicated long term

Need

Quinine

Use short term only when nocturnal leg cramps cause regular disruption of sleep.

Safety

Review effectiveness regularly.

Adherence/Patient centeredness

CAUTION: Thrombocytopenia, blindness, deafness.

Safety

Antianginals

Consider reducing antianginal treatment if mobility has decreased

CAUTION: Hypotension (consider use of other BP lowering drugs; avoid the combination of nitrates with PDE-5 inhibitors)

Safety

Antiarrhythmic - Amiodarone

In AF: Rate control usually has better benefit/risk balance than rhythm control.

Need

CAUTION: Overdosing. Maintenance should be max 200mg/day
CAUTION: Thyroid complications. Ensure monitoring tests are being done
Monitor LFTs

Safety

Statins

Recommended for primary and secondary prevention in patients at high risk of CVD

Effectiveness

CAUTION: Rhabdomyolysis: Check interactions (e.g. fibrates, dihydropyridines, antiinfectives).

Safety

Consider need for and intensity of treatment in light of life expectancy and ADR risk

Aims

BP lowering drugs

Limited evidence supporting tight BP control in the older frail group.

Need

Individualise BP targets for primary and secondary prevention of CVD guidelines.

Effectiveness

Consider need for and intensity of treatment in light of CVD risk life expectancy and ADR risk

Aims

Beta-blockers

Usually essential for rate and angina control in CHD and CHF (and often in AF).

Need

BNF recommends up-titration of beta-blocker doses in CHF to evidence based target doses.

Effectiveness

CAUTION: Bradycardia in combination with diltiazem/verapamil, digoxin and amiodarone.

Safety

ACEI/ARBs

Usually essential for symptom control in CHF. For other potential benefits: see NNT Table

Need

BNF recommends up-titration of ACEI/ARB doses in CHF to evidence based doses.

Effectiveness

CAUTION: Acute Kidney Injury. Avoid combination with NSAIDs and advise patient to stop when at risk of dehydration (See Sick Day Rule Cards).

Safety

CCBs

CAUTION: Constipation, ankle oedema

Dihydropyridines – CAUTION: Reflex tachycardia/cardiodepression: Avoid nifedipine in CHD/CHF

Diltiazem/verapamil – CAUTION: Bradycardia in comb. with beta-blockers or digoxin (digoxin levels increased)

Safety

Spironolactone

Recommended in moderate to severe CHF: See NNT section

Effectiveness

CAUTION: Hyperkalaemia. Risk factors: CKD, combination with ACEI/ARB, triamterene, amiloride
CAUTION: AKI. Avoid combination with NSAIDs and advise patient to stop when at risk of dehydration

Safety