- CAUTION: Gastro-intestinal ADRs (Risk factors: age>75, GI ulcer, antithrombotics, steroids, SSRIs, high alcohol use)
- If NSAIDs are essential: Consider gastro-protection with a PPI in those with GI risk factors
- CAUTION: Cardiovascular ADRs (Risk factors: CVD risk>20%, previous CVD events, heart failure)
- CAUTION: Renal ADRs (Risk factors: age>65, on ACEI, ARBs and/or diuretics, CKD or heart failure
- If NSAIDs are essential: Monitor eGFR; advise patient to stop during intercurrent illness
Chapter 10: Musculoskeletal and joint disease
Assess effectiveness and discuss any need for changes with secondary care specialist
Ensure patient adherence to dosing/monitoring regimen
Adherence/Patient centeredness
CAUTION: Methotrexate overdosing. Avoid preparations with different strengths