1. Cardiac decompensation and/or bradycardia

d. Patient prescribed nitrate and phosphodiesterase type-5 inhib.

Of all people prescribed a nitrate

1332

1.58

h. Patient prescribed beta-blocker and verapamil/diltiazem

Of all people prescribed a beta-blocker

2889

0.72

2. Bleeding

c. Patient prescribed aspirin and another antiplatelet without gastroprotection

Of all people prescribed aspirin

6167

2.25

d. Patient prescribed oral anticoagulant and antiplatelet

Of all people prescribed an oral anticoagulant

6334

6.51

i. Patient  ≥75 years prescribed an NSAID without gastroprotection

Of all people ≥ 75 years

5421

1.28

k. Patient prescribed antiplatelet and NSAID

Of all people prescribed an antiplatelet

18992

5.22

l. Patient prescribed oral anticoagulant and NSAID

Of all people prescribed an anticoagulant

1559

1.60

m. Patient prescribed oral corticosteroids and NSAID

Of all people prescribed an oral corticosteroid

9577

8.62

3. Bone Marrow Suppression

a. Patient prescribed methotrexate without folic acid

Of all people prescribed methotrexate

2689

11.14

b. Patient prescribed two different strengths of methotrexate tablets

Of all people prescribed methotrexate

266

1.10

c. Patient prescribed methotrexate with long-term trimethoprim

Of all people prescribed methotrexate

12

0.05

4 – Acute Kidney Injury

a. Patient prescribed ACEI/ARB and diuretic and NSAID

Of all people prescribed an ACEI or an ARB and a diuretic

11499

5.97

b. Patient ≥65 years  prescribed metformin  and ACEI/ARB and NSAID

Of all people prescribed metformin and an ACEI/ARB

2417

4.67

5 - Hyperkalaemia

b. Patient prescribed  ACEI or ARB and potassium supplement

Of all people prescribed an ACEI or an ARB

709

0.12

c. Patient prescribed  ACEI and ARB

Of all people prescribed an ACEI or an ARB

4764

0.81

d. Patient prescribed all of: (ACEI or ARB) and (spironolactone or eplerenone) and (aliskiren or potassium supplement)

Of all people prescribed an ACEI or an ARB

78

0.01

e. Patient prescribed all of: (ACEI or ARA) and (triamterene or amiloride) and (aliskiren or potassium supplement)

Of all people prescribed an ACEI or an ARA

9

0.00

10 – Hypoglycaemia

a. Patient prescribed insulin without glucose test strips

Of all people prescribed insulin

7410

12.69

14 – Falls, Fractures and Delirium

b. Patient ≥65 years  prescribed THREE or more drugs with sedating or anticholinergic effects (excluding antiepileptics)

Of all people ≥ 65 years

25802

2.85

d. Patient prescribed steroid long term without co-prescription of a bone protecting agent

Of all people prescribed a steroid long term

16092

54.90

15 – Opioids and gabapentinoid dependency

a. Patient prescribed  opioid at dose equivalent to >180 mg morphine per day over last 6 months

Of all people prescribed an opioid

6016

1.11

b. Patient prescribed gabapentin at dose of >4800 mg per day over last 6 months (or equivalent dose of pregabalin)

Of all people prescribed a gabapentanoid

964

0.65

16 – Seizures and neurotoxicity

a. Patient on lithium prescribed an NSAID

Of all people prescribed lithium

262

4.17

b. Patient on lithium recently prescribed a thiazide

Of all people prescribed lithium

6

0.10

17 - Extrapyramidal symptoms

a. Patient prescribed levodopa and metoclopramide long term

Of all people prescribed levodopa

16

0.17

b. Patient ≥65 years prescribed metoclopramide long term^A

Of all people ≥ 65 years

3802

0.42

b.(alt) ≥65 years prescribed metoclopramide long term^B

Of all people ≥ 65 years

2532

0.28