Introduction

No drugs are licensed for the treatment of personality disorder in the UK and evidence for efficacy of drug treatment is scarce. Inappropriate use of medication can impede development of personal responsibility for recovery, impair functioning and contribute to a sense of pessimism when progress does not occur.

The only treatments with evidence of effectiveness in the treatment of personality disorder are psychosocial interventions. When drug treatment is used, it should be as an adjunct to psychosocial interventions. Medication should be avoided as the primary or sole treatment of personality disorder.

When prescribing any medication, please consult the relevant generic guidance on monitoring for adverse effects, maintaining a record of medication, prescribing off-license, and prescribing in pregnancy and breastfeeding. In particular, be aware of guidance cautioning against the use of Valproate in women of child-bearing age.