Antibiotic Dosing
NHS Dumfries & Galloway Antimicrobial Handbook
Children / <18 years old
Refer to: BNFC
Renal / hepatic impairment
Refer to: BNF
/ BNFC , and Renal Drug Database.
Antimicrobial agents reported as "I" (i.e. Susceptible, increased exposure (increased dose))
These agents should not be avoided, but should be given at an increased dose. They remain appropriate treatment options when given at the correct dose:
• Dosing for isolates reported as I: Adults
• Dosing for isolates reported as I: Paediatric
Drug interactions, side effects and safety considerations
An abbreviated list of important considerations can be found within User guide - General, Drug interactions, side effects and safety considerations.
For full list of warnings, drug interactions & side effects please refer to drug-specific sections of the or .
| Antibiotic | Adult Oral Dose Normal hepatic/renal function |
|---|---|
| Aciclovir |
800mg five times daily |
| Amoxicillin |
500mg three times daily |
| Cefalexin |
500mg twice daily |
| Ciprofloxacin |
500mg twice daily
|
| Clarithromycin |
500mg twice daily |
| Co-amoxiclav |
625mg three times daily |
| Co-trimoxazole |
960mg twice daily |
| Doxycycline |
200mg on day one then 100mg daily Severe / osteomyelitis: 200mg on day one then 100mg twice daily |
| Flucloxacillin |
1g four times daily Mild: 500mg four times daily |
| Metronidazole |
400mg three times daily |
| Nitrofurantoin |
50mg four times daily If unavailable: 100mg modified release twice daily  eGFR <30ml/min: Contraindicated eGFR 30-44ml/min: Caution; short term use only |
| Ofloxacin |
200mg twice daily
|
| Penicillin V / Phenoxymethylpenicillin |
500mg four times daily |
| Pivmecillinam |
400mg initial dose then 200mg three times daily. If known ESBL/AmpC: 400mg three times daily |
| Terbinafine |
250mg daily |
| Trimethoprim |
200mg twice daily |