Lisdexamfetamine

Warning

Dosing

Starting dose: 30mg daily in the morning. In patients under the age of 18, or patients who have shown sensitivity to ADHD medication side effects in the past, a starting dose of 20mg may be considered.

Dose escalation: 10-20mg weekly

Maximum dose: 70mg daily, adults and children (6-17 years)

Contraindications

  • Symptomatic cardiovascular disease including moderate to severe hypertension and advanced arteriosclerosis structural cardiac abnormalities
  • Hyper excitability or agitated states
  • Hyperthyroidism, thyrotoxicosis
  • Glaucoma
  • During or for 14 days after treatment with an MAO inhibitor

Adverse effects

Very common: decreased appetite, weight decreased, insomnia, and headache.

Common: Aggression (especially in children), dry mouth, diarrhoea, nausea, vomiting, tachycardia, irritability, fatigue

Uncommon: agitation, dysphoria, buxism, mania, hallucination, dyskinesia, mydriasis, blood pressure increased.

See SPC for full details

Withdrawing treatment

Can be stopped abruptly with no need for gradual reduction.

Editorial Information

Last reviewed: 24/01/2025

Next review date: 01/12/2026

Author(s): PMG-MH.

Version: 1

Approved By: PMG-MH

Reviewer name(s): Lead Clinical Pharmacist, Clinical Effectiveness Pharmacist.