Warning

Dosing

Starting dose: 1mg daily.

Dose escalation: No more than 1mg per week.

Maximum dose: Maximum dose should not exceed 0.12mg/kg.

Age

Weight (kg)

Maximum dose

6-12

≥25

4mg

13-17

34 to 41.4

4mg

13-17

41.5 to 49.5

5mg

13-17

49.5 to 58.4

6mg

13-17

≥58.5

7mg

Adult*

≥58.5

7mg

*Unlicensed

Dose should be reduced by half if concurrent use with moderate or potent inhibitors of CYP3A4 and ciprofloxacin.

Contraindications

  • Hypersensitivity to the active substance or to any of the excipients

Adverse effects

Very common: Headache, somnolence, abdominal pain, fatigue

Common: Decreased appetite, depression, anxiety, insomnia, nightmares, dizziness, sedation, heart rate decreased, blood pressure decrease, nausea, vomiting, diarrhoea, irritability, rash

Uncommon: Agitation, aggression, hallucinations, convulsion, loss of consciousness, dyspepsia, tachycardia, pruritus.

See SPC for full details

Withdrawing treatment

Must be tapered with decrements of no more than 1 mg every 3 to 7 days, and blood pressure and pulse should be monitored to minimise potential withdrawal effects, in particular increases in blood pressure and heart rate.

Editorial Information

Last reviewed: 24/01/2025

Next review date: 01/12/2026

Author(s): PMG-MH.

Version: 1

Approved By: PMG-Mh

Reviewer name(s): Lead Clinical Pharmacist, Clinical Effectiveness Pharmacist.