Post-exposure prophylaxis (PEP) for Hepatitis B

See the needlestick injury immediate care and BBV risk assessment flowchart for recommended actions.

Most HCWs are vaccinated against HBV (and may know their anti-HBs titre). Irrespective of type of exposure:

  • All fully vaccinated HCWs should be offered a HBV booster
  • All non/partially vaccinated HCWs should start/complete a course of HBV vaccine. Those with previous HBV infection require no prophylaxis.

HBV accelerated vaccination

  • Doses at 0, 1 and 2 months (alternatively, 0, 7 & 21 days if more pragmatic) with a booster dose at 12 months.
  • See current BNF for adult and paediatric doses.

 

Administering Hepatitis B immunoglobulin (HBIG)

Where indicated, give HBIG as soon as possible and ideally within 48hrs (but can be considered up to a week post-exposure).

HBIG is held in the RIE Emergency department. Dose:

  • Adult and child over 10yrs, 500IU by IM injection
  • Children <10yrs: contact the paediatric ID consultant at RHCYP (Unavailable: See Where to get expert advice). Do not co-administer HBIG and HBV vaccine at the same site.

 

Follow-up for HBV

  • Those with Significant Exposure should be referred for follow-up testing.
  • Follow up testing should be scheduled as per Table 1.
  • Follow up everyone who received a course of vaccine.
  • Individuals don’t need follow-up HBV testing if they are pre-exposure vaccine responders, and anti-HBS titre >100mIU/ml 2-3 months after a full course of vaccine.