Managing significant exposures

Assess the risk of transmission

Determine risk using the Needlestick injury immediate care and BBV risk assessment flowchart and, if required, the Blood borne viruses – Background information for risk assessment document. This will inform your course of action.

High-risk sources are defined as individuals with a baseline risk of greater than:

  • HIV: 2%
  • HBV: 2.5%

 

Check the vaccination status of injured person

Review the injured person’s HBV vaccination status.

For children, also check tetanus status.

 

Take blood for storage

In every case of Significant Exposure, take a baseline blood sample (4.5ml or 2x2.7ml anti- coagulated EDTA, red cap / clotted sample in children) from the injured party and send to RIE Virology for storage. These samples are kept for 2 years, and in the event of a subsequent positive result for BBV the stored sample helps determine BBV serostatus at time of injury.

Occupational Health offer injured healthcare workers follow-up appointments for storage bloods to at 6, 12 and 24 weeks as required.

 

Follow-up testing

Follow up testing should be offered in all cases but recommended in high-risk scenarios.

The information leaflet Testing for blood borne viruses can be given to patients prior to testing; this contains basic information on BBVs and issues to consider prior to being tested.

Healthcare Workers will be tested (if required or requested) by Occupational Health, unless a course of PEP has been started – in which case follow up testing will be done in RIDU.

There is a professional obligation on certain HCWs to submit to testing when they have been at significant risk.

 

The schedule for follow-up testing is as per Table 1 below:

BBV Test Timing (weeks)
6 12 24
HIV HIV Ag/Ab test Yes Yes No
HBV HBsAg Yes Yes Yes
HBcAb No No Yes
HCV HCV Antibody No Yes Yes
HCV RNA (PCR) Yes Yes No

Table 1. Recommended testing schedule for BBVs after significant exposure event.

Note: If giving HIV PEP, testing occurs 6 and 12 weeks from the end of treatment.

 

Follow up for non-HCWs is undertaken as follows:

1. Adults commenced on HIV Post Exposure Prophylaxis (PEP): Regional Infectious Disease Unit

  • Contact the on-call RIDU registrar via WGH switchboard (0900-2100).
  • Outwith these hours: Obtain a contact number for the injured person and contact the on-call RIDU registrar the next morning. Email the risk assessment form to wgh.infectiousdiseases@nhslothian.scot.nhs.uk.

2. Adults who have not been commenced on HIV PEP: advised to discuss ongoing concerns/arrange follow up testing with their GP

3. Children: contact the on-call paediatric consultant at RHCYP. If unavailable - see section Where to get expert advice.

 

Injured party concern: There will be situations where no significant injury has occurred or transmission risk is low, but patient anxiety may determine the need for referral to RIDU for counselling +/- follow up testing. This is appropriate.

 

Source testing

The injured worker’s line manager should make every effort is made to establish source serostatus. Urgent testing is available, but rarely required (see section Urgent BBV testing in NHS Lothian, below).

 

Source testing panel

  • HIV antigen/antibody
  • HBV surface antigen/core antibody
  • HCV antigen/HCV antibody

 

Informing source patient of test results

  • Test results should be conveyed to the source patient, even if negative.
  • Any source patient who is newly diagnosed with BBV infection as a result of this process will need immediate access to specialist post-test counselling and assurances about confidentiality. This is accessible at RIDU.

 

Obtaining consent

A senior member of the source patient’s clinical team should approach them and ask them to consent to testing.

The injured HCW should not approach the source themselves.

If the HCW sustaining the injury is single-handed, there may be no option but for them to approach the source patient themselves.

In this case, if the source agrees to BBV testing, they should be referred to their GP or A&E. The single-handed practitioner should contact the GP/A&E to discuss the situation.

Brief pre-test discussion and informed consent is required and can be provided by any competent HCW.

 

What to tell the source patient

  • Inform them about the incident and reason for the request for a test.
  • Discuss the exposed HCW’s situation, noting:
    • The benefits of HIV PEP if the source is HIV positive, or
    • If HIV negative, that there are considerable savings in terms of cost, repeat testing and reduced anxiety for the injured person.

Consent to HIV testing is rarely withheld in these circumstances when the approach is made in a sensitive manner.

If consent for testing is withheld or cannot be obtained from the source patient then testing cannot occur.

If the source patient is unconscious they cannot consent; do NOT carry out testing.

 

Urgent BBV testing in NHS Lothian

This is almost never required. In most cases where the risk is considered to be high the injured party can be started on HIV PEP and source status confirmed by non-urgent testing the following day.

For HBV, the only indication for urgent testing is an unvaccinated injured party, where identifying the source as HBV+ would prompt the administration of HBIG.

In extenuating circumstances, urgent source testing can be performed by RIE Virology (results available within 2 hours of arriving at the lab).

 

Urgent testing procedure

  • Make a verbal request to Virology (via RIE switchboard, 0131 536 1000) – either to the Duty Virologist (0900-1700 Mon-Fri) or the Biomedical Scientist on-call outwith these times.
  • Take 4.5ml serum gel (brown cap) blood sample tube
  • Send as follows (either via TRAK or paper form):
  • All patient and requestor details (including contact details)
  • Mark/state ‘Urgent: Exposure incident - Source patient’.