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We are pleased to advise that deep linking capability, enabling users to directly download individual mobile toolkits, has now been released on the RDS mobile app. When you install the update, you will see that each toolkit has a small QR code icon the header area beside the search icon – see screenshot below. Clicking on this icon will open up a window with a full-size QR code and the alternative of a short URL for sharing with users. Instructions are provided.

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Uterine Fibroids, Gynaecology (512)

Warning

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Uterine fibroids (leiomyomas) are common benign tumours found in 25% of women of reproductive age. They may be associated with heavy menstrual bleeding (HMB), pelvic pressure symptoms, subfertility and pregnancy problems.

The malignant potential of fibroids is extremely low (<1%) with leiomyosarcomas typically occuring in women above the age of 60years.

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Editorial Information

Last reviewed: 14/11/2023

Next review date: 31/10/2027

Author(s): Aradhana Khaund.

Version: 4

Co-Author(s): Claire Higgins.

Approved By: Gynaecology Clinical Governance Group

Document Id: 512

References

Fibroids: diagnosis and management. Lumsden MA, Hamoodi I, Gupta J, Hickey M, BMJ 2015;351:h4887

A review of evidence-based management of uterine fibroids K Younas, E Hadoura, F Majoko, A Bunkheila. The Obstetrician & Gynaecologist, 2016;18:33–42

NICE Clinical Knowledge Summaries, Management of Fibroids, May 2022

Liberty 1 & 2 Al-Hendy A et al. N Engl J Med 2021;38:630-642;

Liberty 3 Study Al-Hendy A, et al. Long-term Relugolix Combination Therapy for Symptomatic Uterine Leiomyomas. Obstet Gynecol. 2022 Dec 1;140(6):920-930.

Scottish Medicines Consortium (SMC) advice on new medicines.  SMC2442, relugolix 40mg, estradiol 1mg, norethisterone acetate 0.5mg film-coated tablets (Ryeqo®) May 2022.