Preparation Instructions for Extencilline 2.4MU

Warning

To reduce the pain experienced by patients receiving benzathine and procaine penicillin injections, 1% lidocaine (lignocaine) can be used as an alternative diluent to water for injections (unlicensed indication).

Benzathine Dose: 2.4 Mega units IM weekly for up to 3 weeks.
Presentation: Powder for suspension for injection.
Reconstitute the vial with 8 ml of 1% lidocaine hydrochloride BP solution. Split the resultant suspension into two equal volumes.
The suspension should be administered by deep intramuscular injection in two different sites.

Contraindications

  • Allergy to penicillin or lignocaine.
  • Concomitant anticoagulant therapy.
  • Bleeding diathesis (e.g. Haemophilia).

Precautions
For patients with penicillin allergy, cross reactivity to other beta-lactams such as cephalosporins should be taken into account.

Editorial Information

Last reviewed: 30/09/2022

Next review date: 30/09/2024

Author(s): West of Scotland Managed Clinical Network in Sexual Health Clinical Guidelines Group .

Version: 7.1

Approved By: West of Scotland Managed Clinical Network in Sexual Health